Changes in Uterine Microvessels as a Possible Pathogenic Factor in the Development of Adenomyosis Induced by Pituitary Grafting in Mice.

Yingfang Zhou, Manabu Matsuda, Shinobu Sakamoto, Takao Mori
In: ACTA HISTOCHEMICA ET CYTOCHEMICA · 1999 · vol. 32(5) , pp. 387–391 · doi:10.1267/ahc.32.387 · W2001782447
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This study found that pituitary grafting in mice induced adenomyosis and significantly altered uterine microvessels, increasing dilated venules while decreasing overall microvessel numbers.

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The study quantitatively evaluated uterine microvascular changes during experimental adenomyosis development in mice using immunohistochemistry for von Willebrand factor after pituitary grafting. In all pituitary-grafted mice, slight adenomyosis near the mesometrium was observed 4 weeks post-operation, and uteri with adenomyosis showed significantly increased vessel surface area and minor axis in the endometrium with a tendency toward increased values in the myometrium, while the number of blood vessels decreased significantly in both endometrium and myometrium compared with normal uteri. Dilated venules in the endometrium were frequently found, and regional differences were noted in both control and pituitary-grafted animals. The paper concludes that pituitary grafting significantly increased dilated venules and decreased microvessel number, supporting vascular changes as a possible etiological factor in adenomyosis, relating directly to adenomyosis through its mouse model of experimentally induced adenomyosis.

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Abstract

Changes in uterine blood vessels were evaluated quantitatively by an immunohistochemical study using an antibody to von Willebrand factor (vWF) during the development of experimentally induced adenomyosis in mice. In all mice treated with pituitary grafting, which is a useful method of inducing adenomyosis, slight adenomyosis was found near the mesometrium 4 weeks after the operation. In the uteri with adenomyosis, the mean surface area and minor axis of blood vessels increased significantly in the endometrium and showed a tendency to increase in the myometrium, while the mean number of blood vessels in both endometrium and myometrium decreased significantly compared with those in the normal uteri. The mean percentage of total surface area of blood vessels to mean total tissue area of either endometrium or myometrium was not different in the two groups. Remarkably dilated venules in the endometrium were frequently found in pituitary-grafted mice. In the myometrium, the mean percentage of surface area and mean number of blood vessels were greater in the mesometrial side than in the antimesometrial side in both the control and pituitary-grafted mice. Thus, pituitary grafting significantly increased the number of dilated venules and decreased the number of microvessels in the uterus, suggesting that vascular changes may be one of the important etiological factors for the development of adenomyosis.
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Changes in Uterine Microvessels as a Possible Pathogenic Factor in the Development of Adenomyosis Induced by Pituitary Grafting in Mice 1999 Volume 32 Issue 5 Pages 387-391 Details Abstract Changes in uterine blood vessels were evaluated quantitatively by an immunohistochemical study using an antibody to von Willebrand factor (vWF) during the development of experimentally induced adenomyosis in mice. In all mice treated with pituitary grafting, which is a useful method of inducing adenomyosis, slight adenomyosis was found near the mesometrium 4 weeks after the operation. In the uteri with adenomyosis, the mean surface area and minor axis of blood vessels increased significantly in the endometrium and showed a tendency to increase in the myometrium, while the mean number of blood vessels in both endometrium and myometrium decreased significantly compared with those in the normal uteri. The mean percentage of total surface area of blood vessels to mean total tissue area of either endometrium or myometrium was not different in the two groups. Remarkably dilated venules in the endometrium were frequently found in pituitary-grafted mice. In the myometrium, the mean percentage of surface area and mean number of blood vessels were greater in the mesometrial side than in the antimesometrial side in both the control and pituitary-grafted mice. Thus, pituitary grafting significantly increased the number of dilated venules and decreased the number of microvessels in the uterus, suggesting that vascular changes may be one of the important etiological factors for the development of adenomyosis. © the Japan Society of Histochemistry and Cytochemistry Favorites & Alerts Recently viewed articles

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