Long-Term Responses of the Mouse Uterus to Neonatal Diethylstilbestrol Treatment and to Later Sex Hormone Exposure2
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Neonatal diethylstilbestrol exposure resulted in hypoplastic mouse uteri with smooth muscle abnormalities and metaplastic epithelial cells, but did not alter responses to progesterone.
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Abstract
The effects of ovariectomy at 1 month of age and continuous 17 beta-estradiol (E2) and/or progesterone (P) replacement on the uterus of BALB/cCrgl mice neonatally treated with diethylstilbestrol [(DES) CAS: 56-53-1; alpha-alpha'-diethyl-4,4'-stilbenediol] or sesame oil were recorded after 1, 4, 7, and 10 months of treatment. DES-exposed uteri were found to be hypoplastic, less responsive to the growth-promoting effects of E2, and more likely to develop smooth muscle abnormalities after continuous hormonal treatment than similarly treated control uteri. Neonatal DES treatment led to leukocytic infiltration, disruption in the organization of the inner circular smooth muscle layer, and development of a population of epithelial cells believed to respond to later E2 treatment by proliferation and stratification (squamous metaplasia). Qualitative and quantitative responses to continuous P treatment and the development of cystic glandular hyperplasia and adenomyosis were found to be unaltered by neonatal DES administration. The relevance of these results to the problems of uterine abnormalities observed in women exposed to DES in utero is discussed.
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- Methodological Issues in Preclinical Mouse Efficacy Studies of Adenomyosis 2012
- Canine Uterine Leiomyoma with Epithelial Tissue Foci, Adenomyosis, and Cystic Endometrial Hyperplasia 2011
- Neonatal administration of tamoxifen causes disruption of myometrial development but not adenomyosis in the C57/BL6J mouse 2010
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- Increased invasion activity of endometrial stromal cells and elevated expression of matrix metalloproteinase messenger RNA in the uterine tissues of mice with experimentally induced adenomyosis 2001
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- Changes in Uterine Microvessels as a Possible Pathogenic Factor in the Development of Adenomyosis Induced by Pituitary Grafting in Mice. 1999
- Increased expression of prolactin receptor mRNA in adenomyotic uterus in mice 1997
- Uterine junctional zone: function and disease 1995
- Animal model of uterine adenomyosis: Is prolactin a potent inducer of adenomyosis in mice? 1991
- Adenomyosis: 1989
- Multiple Endocrine Syndrome in SHN Mice: Mammary Tumors and Uterine Adenomyosis 1989
- Ovariectomy of adult mice exposed prenatally to diethylstilbestrol 1987
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