Ovariectomy of adult mice exposed prenatally to diethylstilbestrol
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Ovariectomy of adult mice prenatally exposed to DES at 5-10 weeks or 15 months of age reduced the incidence of genital tract adenocarcinomas compared to non-ovariectomized mice.
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Abstract
Mice exposed prenatally to diethylstilbestrol (DES) were ovariectomized at 5-10 weeks of age, or at 15 months of age. They were maintained to old age and studied for incidence of DES-related pathologic changes. Uterine metaplasia and adenomyosis were not seen after early ovariectomy, but adenomyosis persisted after late ovariectomy. No adenocarcinomas of the genital tract were found in 30 mice ovariectomized early, or in 18 mice ovariectomized at 15 months of age. This result is significantly different from the 14% frequency of genital tract adenocarcinomas reported previously in non-ovariectomized mice of this strain exposed prenatally to DES.
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Cites (2)
- Long-Term Responses of the Mouse Uterus to Neonatal Diethylstilbestrol Treatment and to Later Sex Hormone Exposure<xref ref-type="fn" rid="FN2">2</xref> 1985
- Uterine tumors in old female mice exposed prenatally to diethylstilbestrol. 1983
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References (23)
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- openalex
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