Multiple Endocrine Syndrome in SHN Mice: Mammary Tumors and Uterine Adenomyosis

It is recognized that in laboratory rodents normal and neoplastic mammary gland growth is dependent upon prolactin and the ovarian steroid hormones (estrogen and progesterone) (2, 37, 41). Normal and abnormal proliferation of the uterus is also under the control of similar hormones (6, 8, 14, 25), although the mechanism is not always well understood. Preview Unable to display preview. Download preview PDF. Similar content being viewed by others

Armstrong DT, King ER: Uterine progesterone metabolism and progestational response: effects of estrogens and prolactin. Endocrinology 89:191, 1971. Beuving LT, Bern HA: Hormonal influence upon normal, preneoplastic, and neoplastic mammary gland. In: Estrogen: Target Tissues and Neoplasia. Dao TL ed., p. 257, Chicago & London, Univ. Chicago Press 1972. Colman HI, Rosenthal AH: Carcinoma developing in areas of adenomyosis. Obstet Gynecol 14:342, 1959. Cope E: Adenocarcinoma of the endometrium with malignant stromatosis. J Obstet Gynecol Brit Emp 65:58, 1958. Crossen RJ, Suntzeff V: Endometrial polyps and hyperplasia produced in an aged monkey with estrogen plus progesterone. Arch Pathol 50: 721, 1950. Drill VA: Relationship of estrogens and oral contraceptives to endometrial cancer in animals and women. J Reprod Med 24:5, 1980. Güttner J: Adenomyosis in mice. Z Versuchstierk 22:249, 1980. Heywood R, Wadsworth PF: The experimental toxicology of estrogens. Pharmac Ther 8:125, 1980. Horrobin DF, Lipton A, Muiruri KL, Manku MS, Bramley PS, Burstyn PG: An inhibitory effect of prolactin on the response of rat myometrium to oxytosin. Experientia 29:109, 1973. Huseby RA, Thurlow S: Effects of prenatal exposure of mice to “low-dose” diethylstilbestrol and the development of adenomyosis associated with evidence of hyperprolactinemia. Am J Obstet Gynecol 144:939, 1982. Huseby RA, Soares MJ, Talamantes F: Ectopic pituitary grafts in mice: hormone levels, effects on fertility, and the development of adenomyosis uteri, prolactinomas, and mammary carcinoma. Endocrinology 116:1440, 1985. Joseph MM, Mubako HB: Extraovarian effect of prolactin on the traumatized uterus in the rat. J Reprod Fert 45:413, 1975. Kallad T, Forsberg J. -G, Sinha YN: Long-term effects of neonatal DES treatment on plasma prolactin in female mice. Endocrinol Res Commun 7:157, 1980. Kimura J, Okada H: Uterine tumors and hormone dependency. In Hormone Related Tumors. Nagasawa H, Abe K. eds., p. 201. Tokyo & Berlin, Japan Sci. Soc. Press/Springer-Verlag, 1981. King NW: The reproductive tract. In: Pathology of Laboratory Animals. Benirschke K, Garner FM, Jones TC. eds., vol. 1, chapter 7. p. 510, New York, Heidelberg & Berlin, Springer- Verlag, 1978. Kraus FT: Female genitalia. In: Pathology. Anderson W.A.D.Kissane JM. eds., vol. 2, 7th ed., chapter 40, p. 1680, Saint Louis, The CV Mosby Comp, 1977. Kumar D, Anderson W: Malignancy in endometriosis interna. J Obstet Gynecol Brit Emp 65:435, 1958. Kurman RJ: Benign diseases of the endometrium. In: Pathology of the Female Genital Tract. Blaustein A. ed., 2nd ed., chapter 12. p. 279, New York, Heidelberg & Berlin, Springer-Verlag, 1982. Lacassagne A: Modifications progressives de l’uterus de la souris sous Taction prolongee de l’oestrone. C. r. Séanc Soc Biol 120:1156, 1935. Leung BS, Sasaki GH: Prolactin and progesterone effect on specific estradiol binding in uterine and mammary tissues in vitro. Biochem biophys Res Commun 55:1180, 1973. Lipschiitz A, Iglesias R, Panasevich VI, Salinas S: Pathological changes induced in the uterus of mice with the prolonged administration of progesterone and 19-nor-contraceptives. Brit J Cancer 21:160, 1967. Loeb L, Burns EL, Suntzeff V, Moskop M: Carcinoma-like proliferation in vagina, cervix and uterus of mouse treated with estrogenic hormones. Proc Soc exp Biol Med 35:320, 1936. Marcus CC: Relationship of adenomyosis uteri to endometrial hyperplasia and endometrial carcinoma. Am J Obstet Gynecol 82:408, 1961. Mati JKG, Mugambi M, Muriuki PL, Thairu K: Effect of prolactin on isolated rabbit myometrium. J Endocrinol 60:379, 1974. McKay DG: A review of the status of endometrial cancer. Cancer Res 25:1182, 1965. McLachlan JA, Newbold RR, Bullock BC: Long-term effects on the female mouse genital tract associated with prenatal exposure to diethylstilbestrol. Cancer Res 40:3988, 1980. Meissner WA, Sommers SC, Sherman G: Endometrial hyperplasia, endometrial carcinoma, and endometriosis produced experimentally by estrogen. Cancer 10:500, 1957. Mody JK: Structural changes in the ovaries of IF mice due to age and various other states: Demonstration of spontaneous pseudopregnancy in grouped virgins. Anat Rec 145:439, 1963. Mori T, Bern HA: Longterm effects of neonatal anterior hypophysial isografts on the mammary gland of mammary tumor virus-expressed mice. Proc Soc exp Biol Med 161:48, 1979. Mori T, Nagasawa H: Mechanisms of development of prolac- tin-induced adenomyosis in mice. Acta Anat 116:46, 1983. Mori T, Nagasawa H: Alteration of the development of mammary hyperplastic alveolar nodules and uterine adenomyosis in SHN mice by different schedules of treatment with CB-154. Acta Endocrinol 107:245, 1984. Mori T, Nagasawa H, Takahashi S: The induction of adenomyosis in mice by intrauterine pituitary isografts. Life Sci 29:1277, 1981. Mori T, Nagasawa H, Nakajima Y: Strain-difference in the induction of adenomyosis by intrauterine pituitary grafting in mice. Lab Anim Sci 32:40, 1982. Mori T, Ohta Y, Nagasawa H: Ultrastructural changes in uterine myometrium of mice with experimentally-induced adenomyosis. Experientia 40:1385, 1984. Nagasawa H: Mammary gland DNA synthesis as a limiting factor for mammary tumorigenesis. Forum. IRCS Med Sci 5:405, 1977. Nagasawa H: Prolactin: Its role in the development of mam¬mary tumours. Med Hypoth 5:1117, 1979. Nagasawa H: Hormones and experimental mammary tumorigenesis. In: Hormone Related Tumors. Nagasawa H, Abe K. eds. p. 137, Tokyo, Berlin, Japan Sci. Soc. Press/Springer- Verlag, 1981. Nagasawa H: Causes of age-dependency of mammary tumour induction by carcinogens in rats. Biomedicine 34:9, 1981. Nagasawa H: Prolactin as a promoter of initial progression of spontaneous mammary tumors in mice and lack of relationship to age. Life Sci 33:1451, 1983. Nagasawa H, Yanai R: Frequency of mammary cell division in relation to age: Its significance in the induction of mammary tumors by carcinogen in rats. J Nat Cancer Inst 52:609, 1974. Nagasawa H, Yanai R: Normal and abnormal growth of mammary glands. In: Physiology of Mammary Glands. Yokoyama A, Mizuno H, Nagasawa H. eds., p. 121, Baltimore,Univ. Park Press, 1978. Nagasawa H, Yanai R: Mammary gland prolactin receptor and pituitary prolactin secretion in lactating mice with different lactational performance. Acta Endocrinal 88:94, 1978. Nagasawa H, Morii S: Prophylaxis of spontaneous mammary tumorigenesis by temporal inhibition of prolactin secretion in rats at young ages. Cancer Res 41:1935, 1981. Nagasawa H, Yanai R: The in vitro mammary gland response to mammotropic hormones in mice with different mammary tumorigenesis. Europ J Cancer 17:503, 1981. Nagasawa H, Mori T: Stimulation of mammary tumorigenesis and suppression of uterine adenomyosis by temporary inhibition of pituitary prolactin secretion during youth in mice. Proc Soc exp Biol Med 171:164, 1982. Nagasawa H, Morii S: Inhibition by early treatment with CB-154 (bromocriptine) of spontaneous mammary tumor development in rats with no side-effects. Acta Endocrinol 101:51, 1982. Nagasawa H, Yanai R, Taniguchi H: Reduction by pituitary grafts of mammary tumor age. Its variability in a high mammary tumor strain of mice: Effects on mammary DNA synthesis. Europ J Cancer 12:1017, 1976. Nagasawa H, Yanai R, Taniguchi H: Importance of mammary gland DNA synthesis on carcinogen-induced mammary tumorigenesis in rats. Cancer Res 36:2223, 1976. Nagasawa H, Yanai R, Taniguchi H, Tokuzen R, Nakahara W: Two-way selection of a stock of Swiss albino mice for mammary tumorigenesis: Establishment of two new strains (SHN and SLN). J Natl Cancer Inst 57:425, 1976. Nagasawa H, Mori T, Yanai R, Bern HA, Mills KT: Long- term effects of neonatal hormonal treatments on plasma prolactin levels in female BALB/cfC3H and BALB/c mice. Cancer Res 38:942, 1978. Nagasawa H, Yanai R, Jones LA, Bern HA, Mills KT: Ovarian dependence of the stimulatory effect of neonatal hormone treatment on plasma levels of prolactin in female mice. J Endocrinol 79:391, 1978. Nelson WO: Endometrial and myometrial changes, including fibromatus nodules, induced in the uterus of guinea pig by prolonged administration of oestrogenic hormone. Anat Rec 68:99, 1937. Novak ER, Woodruff JD: Adenomyosis (adenomyoma) uteri. In: Novak’s Gynecologic and Obstetric Pathology with Clinical and Endocrine Relations. Novak ER, Woodruff JD (eds.), 8th ed. ch. 12, p. 280. Philadelphia, London, Toronto, W.B. Saunders Company, 1979. Ostrander PL, Mills KT, Bern HA: Long-term responses of the mouse uterus to neonatal diethylstilbestrol treatment and to later sex hormone exposure. J Natl Cancer Inst 74:121, 1985. Pan SC, Gardner WU: Carcinomas of uterine cervix and vagina in estrogen- and androgen-treated hybrid mice. Cancer Res 8:337, 1948. Posner BI, Kelly PA, Shiu RPC, Friesen HG: Studies of insulin, growth hormone and prolactin binding: tissue distribution, species variation and characterization. Endocrinology 95:521, 1974. Saiduddin S, Zassenhaus HP: Effect of prolactin on specific oestradiol receptors in the rat uterus. J Endocrinol 72:101, 1977. Schwarz OH, Sherman A: Hyperplasia of the endometrium, its relationship to hypertrophy and hyperplasia of the uterine vessels. Am J Obstet Gynecol 59:1330, 1950. Sinha YN: Plasma prolactin analysis as a potential predictor of murine mammary tumorigenesis. In Banbury Report 8: Hormones and Breast Cancer. Dike MC, Süteri PK, Welsch CW. eds., p. 377, New York, Cold Spring Harbor Lab, 1981. Squire RA, Goodman DG, Valerio MG, Fredrickson T, Strandberg JD, Levitt MH, Lingeman CH, Harschbarger JC, Dawe CJ: Female reproductive system. In: Pathology of Laboratory Animals. Benirschke K, Garner FM, Jones TC eds., vol. 2. chapter 12, p. 1172, New York, Heidelberg, Berlin, Springer-Verlag, 1978. Terranova PF, Kent GC: Uterine trauma: Its anabolic effect and influence on uterine sensitivity to prolactin in ovariectomized hamsters. Endocrinology 94:1484, 1974. Vignon F, Rochefort H: Regulation of estrogen receptors in ovarian-dependent rat mammary tumors. I. Effects of castration and prolactin. Endocrinology 98:722, 1976. Vorherr H: Breast cancer. Epidemiology, Endocrinology, Biochemistry and Pharmacology, Baltimore, Munich, Urban, Schwarzenberg, 1980. Vorherr H: Hormones and prostaglandins in relation to breast cancer. In: Hormone Related Tumors. Nagasawa H, Abe K. eds., p. 137. Tokyo, Berlin, Japan Sci. Soc. Press/Springer- Verlag, 1981. Welsch CW, Gribler C: Prophylaxis of spontaneous mammary carcinoma in C3H/HeJ female mice by suppression of prolactin. Cancer Res 33:2939, 1973. Welsch CW; Gribler C, Clemens JA: 6-methyl-8-£- ergolineacetonitrile (MEA)-induced suppression of mammary tumorigenesis in C3H/HeJ female mice. Europ J Cancer 10:595, 1974. Welsch CW, Nagasawa H: Prolactin and murine mammary tumorigenesis: a review. Cancer Res 37:951, 1977. Williams GH; Hammond JM; Weisz J, Mortel R: Binding sites for lactogenic hormone in the rat uterus. Biol Reprod 18:697, 1978. Yanai R, Nagasawa H: Inhibition of mammary tumorigenesis by ergot alkaloids and promotion of mammary tumorigenesis by pituitary isografts in adreno-ovariectomized mice. J Nat Cancer Inst 48:715, 1972. Editor information Editors and Affiliations Rights and permissions Copyright information © 1989 Kluwer Academic Publishers About this chapter Cite this chapter Mori, T., Nagasawa, H. (1989). Multiple Endocrine Syndrome in SHN Mice: Mammary Tumors and Uterine Adenomyosis. In: Kaiser, H.E. (eds) Comparative Aspects of Tumor Development. Cancer Growth and Progression, vol 5. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1091-1_18 Download citation DOI: https://doi.org/10.1007/978-94-009-1091-1_18 Publisher Name: Springer, Dordrecht Print ISBN: 978-94-010-6981-6 Online ISBN: 978-94-009-1091-1 eBook Packages: Springer Book Archive

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