Disturbed Cell Arrangement, Increased Cell Membrane Permeability and Apoptotic Cell Death Occur in Adenomyotic Uterine Tissues in Mice

Megumi Yamashita, Takao Mori
In: Zoological Science · 1997 · vol. 14(4) , pp. 659–664 · doi:10.2108/zsj.14.659 · W2066439824
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Adenomyotic mouse uteri exhibited disordered stromal and muscle cell arrangements, increased myometrial cell membrane permeability, and apoptotic cell death in smooth muscle cells near blood vessels and invading endometrial tissue.

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Yamashita and Mori investigated cellular alterations in the uterine tissues of mice induced with adenomyosis, focusing on structural integrity and cell viability. The researchers observed significant disturbances in normal cell arrangement and increased membrane permeability within the adenomyotic lesions compared to healthy tissue. Furthermore, the study identified elevated rates of apoptotic cell death occurring specifically in the affected uterine regions, indicating active tissue remodeling or damage. This paper is centrally about adenomyosis — specifically examining histological and cellular changes such as apoptosis and membrane permeability in a murine model of the disease.

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Abstract

The relationship of the development of uterine adenomyosis with the changes in the cell arrangement and cell membrane permeability, and incidence of DNA fragmentation was examined in mice. In uterine areas showing the invasion of endometrial tissues into musculature, rhodamine-phalloidin staining for actin fibers revealed that the stromal cells ran parallel to the direction of the infiltration, and the muscle cells lost their regular arrangement, unlike those in the normal uteri of control mice. Inner myometrium showed positive fluorescence with Evans blue, which is known to stain only cells with increased membrane permeability. Outer myometrium also became fluorescence-positive, when the disease was advanced to severe state bearing invasion of endometrial tissues into the outer myometrium. No fluorescence with Evans blue was observed in the normal uterine tissues. Terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick end-labeling (TUNEL method)-positive nuclei were exclusively found in some smooth muscle cells near both the blood vessels and tip of the invading endometrial tissue. These findings indicate that in adenomyotic uteri, apoptotic cell death developed in certain cells in myometrium, though disrupted cell arrangement and increased cell membrane permeability occurred in almost all of the inner myometrial cells. The increased membrane permeability in the myometrial cells might participate in the local occurrence of cell death near the blood vessels. Therefore, endometrial tissue would invade the myometrium through the space produced by the cell death along the blood vessels.
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Disturbed Cell Arrangement, Increased Cell Membrane Permeability and Apoptotic Cell Death Occur in Adenomyotic Uterine Tissues in Mice Authors: Yamashita, Megumi, and Mori, Takao Source: Zoological Science, 14(4) : 659-664 Published By: Zoological Society of Japan URL: https://doi.org/10.2108/zsj.14.659 The BioOne Digital Library (https://bioone.org/) provides worldwide distribution for more than 580 journals and eBooks from BioOne’s community of over 150 nonprofit societies, research institutions, and university presses in the biological, ecological, and environmental sciences. The BioOne Digital Library encompasses the flagship aggregation BioOne Complete (https://bioone.org/subscribe), the BioOne Complete Archive (https://bioone.org/archive), and the BioOne eBooks program offerings ESA eBook Collection (https://bioone.org/esa-ebooks) and CSIRO Publishing BioSelect Collection (https://bioone.org/csiro- ebooks). Your use of this PDF, the BioOne Digital Library, and all posted and associated content indicates your acceptance of BioOne’s Terms of Use, available at www.bioone.org/terms-of-use. Usage of BioOne Digital Library content is strictly limited to personal, educational, and non-commmercial use. Commercial inquiries or rights and permissions requests should be directed to the individual publisher as copyright holder. BioOne is an innovative nonprofit that sees sustainable scholarly publishing as an inherently collaborative enterprise connecting authors, nonprofit publishers, academic institutions, research libraries, and research funders in the common goal of maximizing access to critical research. Downloaded From: https://bioone.org/journals/Zoological-Science on 05 Sep 2026 Terms of Use: https://bioone.org/terms-of-use Downloaded From: https://bioone.org/journals/Zoological-Science on 05 Sep 2026 Terms of Use: https://bioone.org/terms-of-use Downloaded From: https://bioone.org/journals/Zoological-Science on 05 Sep 2026 Terms of Use: https://bioone.org/terms-of-use Downloaded From: https://bioone.org/journals/Zoological-Science on 05 Sep 2026 Terms of Use: https://bioone.org/terms-of-use Downloaded From: https://bioone.org/journals/Zoological-Science on 05 Sep 2026 Terms of Use: https://bioone.org/terms-of-use Downloaded From: https://bioone.org/journals/Zoological-Science on 05 Sep 2026 Terms of Use: https://bioone.org/terms-of-use Downloaded From: https://bioone.org/journals/Zoological-Science on 05 Sep 2026 Terms of Use: https://bioone.org/terms-of-use

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adenomyosis

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