A Baboon Model for Inducing Endometriosis

Asgerally T Fazleabas, Fazleabas AT
Methods in molecular medicine · 2005 · vol. 121 , pp. 093–098 · doi:10.1385/1-59259-983-4:093 · PMID:16251737 · W2438764490
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-07 ⓘ

Researchers developed an induced baboon model that recapitulates spontaneous endometriosis, allowing for the study of progressive endometrial changes in ectopic and eutopic tissue.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 · read from full text ⓘ

This paper describes the development of an induced baboon model to study early and progressive events in endometriosis, using intrapelvic induction that recapitulates spontaneous disease and enables examination of ectopic and eutopic endometrium at specific menstrual-cycle times. The approach is intended to clarify systemic, time-dependent mechanisms relevant to establishment of disease and infertility, which are difficult to assess in women. A major caveat is that the work is framed as a model/protocol development rather than a direct mechanistic test of human disease, and its fidelity is described in terms of disease recapitulation rather than proven equivalence. This paper is centrally about endometriosis — it presents and motivates a baboon model for inducing and studying the disease progression.

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Abstract

Endometriosis is a disease that is associated with severe pelvic pain and is a major cause of infertility in women. It is an enigmatic disease whose etiology and pathophysiology has been studied to a limited extent. The events associated with the establishment of the disease and mechanisms associated with infertility are difficult to assess in a systemic manner in women. In order to understand the early and progressive events associated with the establishment of the disease, we have developed a baboon model in which the disease can be induced. This induction manifests itself in a manner that recapitulates the spontaneous disease. The advantage of the induced model is that the progressive changes in both the ectopic and eutopic endometrium can be studied in a nonhuman primate model at specific times during the menstrual cycle and as the disease process continues.
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Abstract

Endometriosis is a disease that is associated with severe pelvic pain and is a major cause of infertility in women. It is an enigmatic disease whose etiology and pathophysiology has been studied to a limited extent. The events associated with the establishment of the disease and mechanisms associated with infertility are difficult to assess in a systemic manner in women. In order to understand the early and progressive events associated with the establishment of the disease, we have developed a baboon model in which the disease can be induced. This induction manifests itself in a manner that recapitulates the spontaneous disease. The advantage of the induced model is that the progressive changes in both the ectopic and eutopic endometrium can be studied in a nonhuman primate model at specific times during the menstrual cycle and as the disease process continues. Similar content being viewed by others

References

Eskenazi, B. and Warner, M. L. (1997) Epidemiology of endometriosis. Obstet. Gynecol. Clin. North Am. 24, 235–258. Gruppo italiano. (1994) Prevalence and anatomical distribution of endometriosis in women with selected gynaecological conditions: results from a multicentric Italian study. Gruppo italiano per lo studio dell’endometriosi. Hum. Reprod. 9, 1158–1162. Sampson, J. A. (1927) Peritoneal endometriosis due to menstrual dissemination of endometrial tissue into the peritoneal cavity. Am. J. Obstet. Gynecol. 14, 422–469. D’Hooghe, T. M. (1997) Clinical relevance of the baboon as a model for the study of endometriosis. Fertil. Steril. 68, 613–625. D’Hooghe, T. M., Bambra, C. S., Raeymaekers, B. M., De Jonge, I., Lauweryns, J. M. and Koninckx, P. R. (1995) Intrapelvic injection of menstrual endometrium causes endometriosis in baboons (Papio cynocephalus and Papio anubis). Am. J. Obstet. Gynecol. 173, 125–134. Fazleabas, A. T., Brudney, A., Gurates, B., Chai, D., and Bulun, S. E. (2002) A primate model for endometriosis, in Proceedings of a NIH Workshop on Endometriosis: Emerging Research and Intervention Strategies (Yoshinaga, K. and Parrot, E., eds.). Ann. N. Y. Acad. Sci. 955, 308–317. Fazleabas, A. T., Brudney, A., Chai, D., Langoi, D., and Bulun, S. E. (2003) Steroid receptor and aromatase expression in baboon endometriotic lesions. Fertil. Steril. 80(Suppl 2), 820–827. D’Hooghe, T. M., Bambra, C. S., Raeymaekers, B. M., and Koninckx, P. R. (1996) Serial laparoscopies over 30 months show that endometriosis in captive baboons (Papio anubis, Papio cynocephalus) is a progressive disease. Fertil. Steril. 65, 645–649. Fazleabas, A. T., Miller, J. B., and Verhage, H. G. (1988) Synthesis of estrogen and progesterone dependent proteins by the baboon (Papio anubis) endometrium. Biol. Reprod. 39, 729–736. Author information Authors and Affiliations Editor information Editors and Affiliations Rights and permissions Copyright information © 2006 Humana Press Inc. About this protocol Cite this protocol Fazleabas, A.T. (2006). A Baboon Model for Inducing Endometriosis. In: Soares, M.J., Hunt, J.S. (eds) Placenta and Trophoblast. Methods in Molecular Medicine™, vol 121. Humana Press. https://doi.org/10.1385/1-59259-983-4:093 Download citation DOI: https://doi.org/10.1385/1-59259-983-4:093 Publisher Name: Humana Press Print ISBN: 978-1-58829-404-3 Online ISBN: 978-1-59259-983-7 eBook Packages: Springer Protocols

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Condition tags

endometriosisinfertility

MeSH descriptors

Disease Models, Animal Endometriosis Papio Animals Endometriosis Endometrium Endometrium Female

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