Translational In Vivo Models for Women’s Health: The Nonhuman Primate Endometrium—A Predictive Model for Assessing Steroid Receptor Modulators

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Nonhuman primates like macaques and baboons are described as useful preclinical models for studying menstruation and endometriosis and for evaluating reproductive therapies due to their similar physiological responses to steroid hormones as women.

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This chapter discusses translational in vivo models in nonhuman primates, focusing on why macaques and baboons have reproductive and steroid-hormone responses similar to women, and describing how these species are used to study menstruation, endometriosis, and to evaluate reproductive therapies and contraceptives. It outlines the strengths of nonhuman primate systems for preclinical development aimed at improved therapies for women. A stated caveat is not a specific experimental limitation but the chapter’s scope as an overview that summarizes uses rather than presenting new experimental results. Relevance to endometriosis: the paper explicitly frames nonhuman primates as models used for “preclinical studies on menstruation, endometriosis,” though its main focus is a broader review of predictive nonhuman primate endometrium models for steroid receptor modulators.

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Abstract

Macaques and baboons display physiological responses to steroid hormones that are similar to those of women. Herein, we describe various uses of nonhuman primates for preclinical studies on menstruation, endometriosis, and as a model system to evaluate reproductive therapies and contraceptives. Our goal is to outline the strengths of the nonhuman primate model for studies leading to improved therapies for women.
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Abstract

Macaques and baboons display physiological responses to steroid hormones that are similar to those of women. Herein, we describe various uses of nonhuman primates for preclinical studies on menstruation, endometriosis, and as a model system to evaluate reproductive therapies and contraceptives. Our goal is to outline the strengths of the nonhuman primate model for studies leading to improved therapies for women. Access this chapter Tax calculation will be finalised at checkout Purchases are for personal use only Similar content being viewed by others

References

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Hum Reprod 13:2132–2138 Zelinski-Wooten MB, Slayden OD, Chwalisz K, Hess DL, Brenner RM, Stouffer RL (1998b) Chronic treatment of female rhesus monkeys with low doses of the antiprogestin ZK 137 316: establishment of a regimen that permits normal menstrual cyclicity. Hum Reprod 13:259–267 Acknowledgment Work presented herein was supported by the following grants from the National Institutes of Health: HD43209, HD18185, RR00163, and OD011092. Author information Authors and Affiliations Corresponding author Editor information Editors and Affiliations Rights and permissions Copyright information © 2015 Springer International Publishing Switzerland About this chapter Cite this chapter Slayden, O.D. (2015). Translational In Vivo Models for Women’s Health: The Nonhuman Primate Endometrium—A Predictive Model for Assessing Steroid Receptor Modulators. In: Nielsch, U., Fuhrmann, U., Jaroch, S. (eds) New Approaches to Drug Discovery. Handbook of Experimental Pharmacology, vol 232. Springer, Cham. https://doi.org/10.1007/164_2015_22 Download citation DOI: https://doi.org/10.1007/164_2015_22 Publisher Name: Springer, Cham Print ISBN: 978-3-319-28912-0 Online ISBN: 978-3-319-28914-4 eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)

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MeSH descriptors

Endometrium Receptors, Steroid Women's Health Animals Endometrium Female Humans Menstruation Menstruation Models, Animal Primates Receptors, Steroid

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