{"paper_id":"c2608425-a545-4278-b233-5e3b7d9149b2","body_text":"Abstract\nEndometriosis is a disease that is associated with severe pelvic pain and is a major cause of infertility in women. It is an enigmatic disease whose etiology and pathophysiology has been studied to a limited extent. The events associated with the establishment of the disease and mechanisms associated with infertility are difficult to assess in a systemic manner in women. In order to understand the early and progressive events associated with the establishment of the disease, we have developed a baboon model in which the disease can be induced. This induction manifests itself in a manner that recapitulates the spontaneous disease. The advantage of the induced model is that the progressive changes in both the ectopic and eutopic endometrium can be studied in a nonhuman primate model at specific times during the menstrual cycle and as the disease process continues.\nSimilar content being viewed by others\nReferences\nEskenazi, B. and Warner, M. L. (1997) Epidemiology of endometriosis. Obstet. Gynecol. Clin. North Am. 24, 235–258.\nGruppo italiano. (1994) Prevalence and anatomical distribution of endometriosis in women with selected gynaecological conditions: results from a multicentric Italian study. Gruppo italiano per lo studio dell’endometriosi. Hum. Reprod. 9, 1158–1162.\nSampson, J. A. (1927) Peritoneal endometriosis due to menstrual dissemination of endometrial tissue into the peritoneal cavity. Am. J. Obstet. Gynecol. 14, 422–469.\nD’Hooghe, T. M. (1997) Clinical relevance of the baboon as a model for the study of endometriosis. Fertil. Steril. 68, 613–625.\nD’Hooghe, T. M., Bambra, C. S., Raeymaekers, B. M., De Jonge, I., Lauweryns, J. M. and Koninckx, P. R. (1995) Intrapelvic injection of menstrual endometrium causes endometriosis in baboons (Papio cynocephalus and Papio anubis). Am. J. Obstet. Gynecol. 173, 125–134.\nFazleabas, A. T., Brudney, A., Gurates, B., Chai, D., and Bulun, S. E. (2002) A primate model for endometriosis, in Proceedings of a NIH Workshop on Endometriosis: Emerging Research and Intervention Strategies (Yoshinaga, K. and Parrot, E., eds.). Ann. N. Y. Acad. Sci. 955, 308–317.\nFazleabas, A. T., Brudney, A., Chai, D., Langoi, D., and Bulun, S. E. (2003) Steroid receptor and aromatase expression in baboon endometriotic lesions. Fertil. Steril. 80(Suppl 2), 820–827.\nD’Hooghe, T. M., Bambra, C. S., Raeymaekers, B. M., and Koninckx, P. R. (1996) Serial laparoscopies over 30 months show that endometriosis in captive baboons (Papio anubis, Papio cynocephalus) is a progressive disease. Fertil. Steril. 65, 645–649.\nFazleabas, A. T., Miller, J. B., and Verhage, H. G. (1988) Synthesis of estrogen and progesterone dependent proteins by the baboon (Papio anubis) endometrium. Biol. Reprod. 39, 729–736.\nAuthor information\nAuthors and Affiliations\nEditor information\nEditors and Affiliations\nRights and permissions\nCopyright information\n© 2006 Humana Press Inc.\nAbout this protocol\nCite this protocol\nFazleabas, A.T. (2006). A Baboon Model for Inducing Endometriosis. In: Soares, M.J., Hunt, J.S. (eds) Placenta and Trophoblast. Methods in Molecular Medicine™, vol 121. Humana Press. https://doi.org/10.1385/1-59259-983-4:093\nDownload citation\nDOI: https://doi.org/10.1385/1-59259-983-4:093\nPublisher Name: Humana Press\nPrint ISBN: 978-1-58829-404-3\nOnline ISBN: 978-1-59259-983-7\neBook Packages: Springer Protocols","source_license":"CC0","license_restricted":false}