Molecular Pathology and Therapy of Endometriosis: Revisited

Padmanaban S. Suresh
In: Andrology & Gynecology: Current Research · 2013 · vol. 01(03) · doi:10.4172/2327-4360.1000105 · W2323351786
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This review revisits the molecular pathology and therapy of endometriosis, highlighting the complex, multifactorial nature of the disease and the ongoing challenges in understanding its etiopathogenesis.

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This article is a narrative review revisiting molecular pathology and therapeutic considerations in endometriosis, focusing on what is known about its etiopathogenesis in women of reproductive age. It describes endometriosis as a complex, hormone-dependent, multifactorial condition involving interactions among genetic, immunological, hormonal, and environmental factors. The authors report that while molecular mechanisms have been investigated intensely over the past decade, the overall causes and pathogenesis remain incompletely understood, a caveat supported by the scarcity of clear mechanistic understanding and by setbacks in clinical trials. This paper is centrally about endometriosis — it revisits the molecular pathways implicated in endometriosis and how those mechanisms relate to therapy.

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Abstract

Molecular Pathology and Therapy of Endometriosis: Revisited Endometriosis is among one of the most challenging diseases of the 21st century that affects women in their reproductive age, and its aetiology and pathogenesis remains enigmatic. Unravelling the molecular mechanisms that play a role in the etiopathogenesis of endometriosis has been the subject of intense investigation over the last decade. It is a complex hormone dependent and multifactorial disease involving intricate communications of genetic, immunological, hormonal and environmental factors and the clear understanding of the etiopathogenesis of endometriosis is scarce, as indicated by many studies and recent setbacks in clinical trials.
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Review Article, Androl Gynecol Curr Res Vol: 1 Issue: 3 Molecular Pathology and Therapy of Endometriosis: Revisited | Padmanaban S Suresh1*, Thejaswini Venkatesh2, Thangarasu Rajan3 and Rie Tsutsumi4 | | | 1Centre for Biomedical Research, Vellore Institute of Technology (VIT), Tamilnadu, India | | | 2Dept of Molecular Reproduction, Development and Genetics, Indian Institute of Science, Bangalore, India | | | 3Aarupadai Veedu Medical College and Hospital, Puducherry, India | | | 4University of Tokushima, Institute of Health Bioscience, Department of Public health and nutrition, Japan | | | Corresponding author : Suresh PS, PhD Centre for Biomedical Research, Vellore Institute of Technology, VIT University, Vellore - 632 014, Tamilnadu, India Tel: 91-9597872269; E-mail: [email protected] | | | Received: April 05, 2013 Accepted: May 17, 2013 Published: May 22, 2013 | | | Citation: Suresh PS, Venkatesh T, Rajan T, Tsutsumi R (2013) Molecular Pathology and Therapy of Endometriosis: Revisited. Androl Gynecol: Curr Res 1:3. doi:10.4172/2327-4360.1000105 | Abstract Molecular Pathology and Therapy of Endometriosis: Revisited Endometriosis is among one of the most challenging diseases of the 21st century that affects women in their reproductive age, and its aetiology and pathogenesis remains enigmatic. Unravelling the molecular mechanisms that play a role in the etiopathogenesis of endometriosis has been the subject of intense investigation over the last decade. It is a complex hormone dependent and multifactorial disease involving intricate communications of genetic, immunological, hormonal and environmental factors and the clear understanding of the etiopathogenesis of endometriosis is scarce, as indicated by many studies and recent setbacks in clinical trials.

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