Anti‐laminin‐1 Autoantibodies, Pregnancy Loss and Endometriosis

Junko Inagaki, Akane Kondo, Luis R Lopez, Yehuda Shoenfeld, Eiji Matsuura
Clinical & developmental immunology · 2004 · vol. 11(3-4) , pp. 261–266 · doi:10.1080/17402520400001678 · PMID:15559372 · W2086636827
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Anti-laminin-1 antibodies, found in women with recurrent pregnancy loss and endometriosis-associated infertility, react with laminin-1 chains and may contribute to reproductive failure.

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Abstract

Laminin-1 is a major component and multifunctional glycoprotein of basement membranes that consists of three different subunits, alpha1, beta1 and gamma11 chains. It is the earliest synthesized network-forming protein during embryogenesis and plays an important role in embryonic development, embryonic implantation and placentation. We have recently shown that IgG anti-laminin-1 antibodies were significantly associated with recurrent first-trimester miscarriages and with subsequent pregnancy outcome. Interestingly, these antibodies were also observed in patients with endometriosis-associated infertility but not in patients with other causes of infertility, including tubal factors, hormonal and uterine abnormalities. Laminin-alpha1, -beta1 and -gamma1 mRNAs have been detected in 90% of endometriotic lesions and all laminin-alpha1, -beta1 and -gamma1 chains were localized in the basement membranes of glandular epithelium in endometriotic peritoneal lesions. Western blot analysis showed that anti-laminin-1 antibodies from those patients reacted with all laminin-1's chains. ELISA also confirmed that one of the target epitopes for these antibodies was located in a particular region of the laminin-1 molecule, i.e. the carboxyl-terminal globular G domain of alpha1 chain. IgM monoclonal anti-laminin-1 autoantibody, that we recently established, also recognized the G domain. Anti-laminin-1 antibodies from mice immunized with "mouse" laminin-1, caused a higher fetal resorption rate with lower embryonic and placental weights. Thus, anti-laminin-1 antibodies may be important in development of autoimmune-mediated reproductive failures and the assessment of the antibodies may provide a novel non-invasive diagnosis of endometriosis.

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Condition tags

mesh:D004715endometriosisinfertility

MeSH descriptors

Abortion, Habitual Autoantibodies Endometriosis Laminin Abortion, Habitual Adult Animals Autoantibodies Endometriosis Endometriosis Female Humans Immunoglobulin G Immunoglobulin G Immunoglobulin M Immunoglobulin M Infertility, Female Infertility, Female Infertility, Female Laminin

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References (23)

Cited by (6)

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