Endometriosis-Associated Pain – Do Preclinical Rodent Models Provide a Good Platform for Translation?

Erin Greaves, Matthew Rosser, Philippa T K Saunders
Advances in anatomy, embryology, and cell biology · 2020 · vol. 232 , pp. 25–55 · doi:10.1007/978-3-030-51856-1_3 · PMID:33278006 · W3110472901
review OA: closed CC0 ⤵ 10 in-corpus citations
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-06 ⓘ

Rodent models replicate key pain mechanisms in endometriosis, but limited lesion types and evoked pain tests restrict translation, necessitating improved models and spontaneous pain measurements.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-06 ⓘ

This review assesses evidence on whether mechanisms such as different lesion subtypes, extra-uterine bleeding, and neuropathic pathways explain the complex, heterogeneous pelvic pain experienced by women with endometriosis, focusing on preclinical rodent studies. It summarizes rodent endometriosis models that use behavioral pain endpoints (evoked and non-evoked), highlighting replication of mechanisms including lesion innervation, immune-cell pronociceptive molecules activating nerves, and estrogen’s modulation of hyperalgesia, with some models showing spinal cord and brain changes resembling patient-reported changes. The paper’s main limitation is that many studies rely on models producing only superficial lesions and use mostly induced (evoked) pain tests, which may restrict translation. This paper is centrally about endometriosis—specifically evaluating how well preclinical rodent models capture endometriosis-associated pain and where they fall short for translation.

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Condition tags

mesh:D004715mesh:D017699endometriosis

MeSH descriptors

Endometriosis Pelvic Pain Uterus Animals Disease Models, Animal Endometriosis Endometriosis Endometriosis Female Humans Mice Pelvic Pain Pelvic Pain Pelvic Pain Rats Uterus Uterus

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Cited by (10)

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License: CC0 · commercial use OK