Pre-clinical Models of Endometriosis: A Focus on Chronic Pain

Jessica Maddern, Stuart M. Brierley, Joel Castro
In: Visceral Pain · 2023 · pp. 209–222 · doi:10.1007/978-3-031-25702-5_16 · W4360781155
book-chapter OA: closed CC0
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-06 ⓘ

Pre-clinical animal models of endometriosis that incorporate multiple behavioral techniques can recapitulate diverse pain attributes, offering a more comprehensive approach to uncovering pain mechanisms.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-06 ⓘ

This chapter discusses how small animal models of endometriosis have been used to study mechanisms of chronic pelvic pain (CPP), noting that most studies emphasize disease development rather than the neurobiological basis of endometriosis-associated pain. Across studies that incorporate established behavioral assays, the authors report that these models can recapitulate multiple key clinical pain attributes seen in women, including widespread and comorbid pain. A major limitation highlighted is that many experiments use only one or two behavioral techniques targeting a single symptom, which constrains mechanistic understanding of diverse, cross-organ pain states. This paper is centrally about endometriosis — it focuses on pre-clinical model strategies for understanding and measuring endometriosis-associated chronic pain.

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endometriosis

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last seen: 2026-06-10T17:14:06.276822+00:00
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