Histological classification of endometriosis as a predictor of response to treatment

M S Abrao, Maurício Simões Abrão, Rosa Maria Neme, R M Neme, Filomena Marino Carvalho, F M Carvalho, José Mendes Aldrighi, J M Aldrighi, José Aristodemo Pinotti, J A Pinotti
International Journal of Gynecology & Obstetrics · 2003 · vol. 82(1) , pp. 31–40 · doi:10.1016/s0020-7292(03)00079-1 · PMID:12834939 · W2016150863
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This study found that histological patterns of endometriosis correlate with disease stage and location, and differentiated or stromal types predict better pain relief response to treatment than undifferentiated types.

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Abstract

OBJECTIVES: To evaluate the usefulness of the histological classification of endometriosis in predicting responses to treatment. METHODS: We evaluated 412 biopsy specimens from 241 patients with pelvic endometriosis. Pain and infertility were evaluated before surgery. Disease location and stage of development were analyzed according to the 1985 American Society of Reproductive Medicine (ASRM) classification. Histological findings were classified as stromal, well-differentiated, undifferentiated, and mixed endometriosis. Clinical response to pain or infertility was evaluated. RESULTS: Histological findings, disease location and stage of development, and response to treatment were compared. Undifferentiated endometriosis was more frequently associated with stages III/IV than the well-differentiated and stromal histological types. Pure or mixed undifferentiated patterns were more frequently associated with rectovaginal endometriosis. When considering pain symptoms, patients presenting well-differentiated or stromal histological patterns responded better to therapeutic treatment than those who presented undifferentiated histological patterns. There were no significant differences in cases related to sterility. CONCLUSIONS: The histological categorization of endometriosis can help predict the behavioral patterns of the disease.

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Condition tags

mesh:D004715endometriosisbowel_endometriosisinfertility

MeSH descriptors

Endometriosis Endometriosis Infertility, Female Pain Management Adolescent Adult Antineoplastic Agents, Hormonal Antineoplastic Agents, Hormonal Endometriosis Endometriosis Endometriosis Female Goserelin Goserelin Gynecologic Surgical Procedures Gynecologic Surgical Procedures Humans Infertility, Female Infertility, Female Pain

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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License: CC0 · commercial use OK