Functional Expression of FSH Receptor in Endometriotic Lesions

Donata Ponikwicka-Tyszko, Donata Ponikwicka‐Tyszko, Marcin Chrusciel, Marcin Chruściel, Joanna Stelmaszewska, Piotr Bernaczyk, Maria Sztachelska, Iwona Sidorkiewicz, Milena Doroszko, Jakub Tomaszewski, Juha S Tapanainen, Ilpo Huhtaniemi, Sławomir Wołczyński, Slawomir Wolczynski, Nafis A Rahman
The Journal of clinical endocrinology and metabolism · 2016 · vol. 101(7) , pp. 2905–2914 · doi:10.1210/jc.2016-1014 · PMID:27224263 · W2407743148
article OA: bronze CC0 ⤵ 7 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This study found functional FSH receptor expression in endometriotic lesions, where FSH stimulation increased estrogen production and gene expression, suggesting a role in disease pathology.

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Abstract

CONTEXT: FSH receptor (FSHR), besides being expressed in gonads, is also expressed in some extragonadal tissues at low levels. OBJECTIVE: We examined the functional expression of FSHR in different types of endometriotic lesions. DESIGN: Extensive studies were carried out to detect functional FSHR expression and FSH-stimulated estrogen production in ovarian endometriomas and recto-vaginal endometriotic nodules (RVEN). Normal endometrium, ovary, and myometrium tissues from nonpregnant cycling women served as controls. SETTINGS: This laboratory-based study was carried out on tissue specimens from patients with endometriosis and healthy donors. RESULTS: Endometriotic lesions and normal secretory-phase endometrium showed FSHR expression at both mRNA and protein level. RVEN and ovarian endometrioma demonstrated up-regulated CYP19A1, dependent on the activation of CYP19A1 proximal promoter II. Estrogen receptor-β (ESR2) expression was significantly increased in RVEN vs normal endometrium. Recombinant human FSH stimulation of RVEN explants significantly increased estradiol production and CYP19A1 and ESR2 expression. FSHR was up-regulated in recombinant human FSH-stimulated endometrial and decidualized stromal cells with increased CYP19A1 expression. CONCLUSIONS: We described a novel functional FSHR expression, where FSH-stimulated CYP19A1 expression and estrogen production in RVEN are demonstrated. This locally FSH-induced estrogen production may contribute to the pathology, development, progression, and severity of RVEN.

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Condition tags

endometriosisendometrioma

MeSH descriptors

Aromatase Endometriosis Endometrium Receptors, FSH Rectal Diseases Vaginal Diseases Adult Aromatase Aromatase Case-Control Studies Endometriosis Endometriosis Endometrium Endometrium Endometrium Estradiol Estradiol Estrogen Receptor beta Estrogen Receptor beta Female

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