Functional Expression of FSH Receptor in Endometriotic Lesions

Donata Ponikwicka‐Tyszko, Donata Ponikwicka-Tyszko, Chrusciel M, Marcin Chrusciel, Marcin Chruściel, Joanna Stelmaszewska, Piotr Bernaczyk, Maria Sztachelska, Iwona Sidorkiewicz, Doroszko M, Milena Doroszko, Tomaszewski J, Jakub Tomaszewski, Juha S. Tapanainen, Tapanainen JS, Huhtaniemi I, Ilpo Huhtaniemi, Slawomir Wolczynski, Sławomir Wołczyński, Nafis A. Rahman, Rahman NA
The Journal of clinical endocrinology and metabolism · 2016 · vol. 101(7) , pp. 2905–2914 · doi:10.1210/jc.2016-1014 · PMID:27224263 · W2407743148
Other OA: bronze CC0 ⤵ 7 in-corpus citations
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This study found functional FSH receptor expression in endometriotic lesions, where FSH stimulation increased estrogen production and gene expression, suggesting a role in disease pathology.

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Abstract

CONTEXT: FSH receptor (FSHR), besides being expressed in gonads, is also expressed in some extragonadal tissues at low levels. OBJECTIVE: We examined the functional expression of FSHR in different types of endometriotic lesions. DESIGN: Extensive studies were carried out to detect functional FSHR expression and FSH-stimulated estrogen production in ovarian endometriomas and recto-vaginal endometriotic nodules (RVEN). Normal endometrium, ovary, and myometrium tissues from nonpregnant cycling women served as controls. SETTINGS: This laboratory-based study was carried out on tissue specimens from patients with endometriosis and healthy donors. RESULTS: Endometriotic lesions and normal secretory-phase endometrium showed FSHR expression at both mRNA and protein level. RVEN and ovarian endometrioma demonstrated up-regulated CYP19A1, dependent on the activation of CYP19A1 proximal promoter II. Estrogen receptor-β (ESR2) expression was significantly increased in RVEN vs normal endometrium. Recombinant human FSH stimulation of RVEN explants significantly increased estradiol production and CYP19A1 and ESR2 expression. FSHR was up-regulated in recombinant human FSH-stimulated endometrial and decidualized stromal cells with increased CYP19A1 expression. CONCLUSIONS: We described a novel functional FSHR expression, where FSH-stimulated CYP19A1 expression and estrogen production in RVEN are demonstrated. This locally FSH-induced estrogen production may contribute to the pathology, development, progression, and severity of RVEN.

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Condition tags

endometriosisendometrioma

MeSH descriptors

Aromatase Endometriosis Endometrium Receptors, FSH Rectal Diseases Vaginal Diseases Adult Adult Aromatase Aromatase Aromatase Case-Control Studies Case-Control Studies Endometriosis Endometriosis Endometriosis Endometrium Endometrium Endometrium Endometrium

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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