Classificação histológica e qualidade de vida em mulheres portadoras de endometriose

Beatriz Taliberti da Costa Porto, Helizabet Salomão Abdalla Ayrosa Ribeiro, Maria Antonieta Longo Galvão, Vanessa Gozzo Sekula, José Mendes Aldrigui, Paulo Augusto Ayrosa Ribeiro, Paulo Ayroza Ribeiro
Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2015 · vol. 37(2) , pp. 87–93 · doi:10.1590/so100-720320140004650 · PMID:25760628 · W2007003830
article OA: diamond CC0 ⤵ 11 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This study investigated the link between endometriosis histological subtypes and quality of life in women, finding that the mixed subtype in the intestine correlated with improved social and emotional aspects post-surgery.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-09 ⓘ

Este estudo observacional transversal avaliou 40 mulheres com endometriose profunda submetidas a cirurgia laparoscópica, analisando 32 biópsias de intestino, peritônio e ligamento uterossacro e classificando a morfologia histológica como glandular indiferenciada (GI) ou mista (GM) (além de outras categorias, mas apenas GI/GM permaneceram na amostra para a análise). A qualidade de vida foi medida pelo SF-36 antes da cirurgia e aos 6 e 12 meses, e os autores verificaram associação entre tipo histológico e evolução de domínios do SF-36, sobretudo nas lesões intestinais: apenas o tipo GM mostrou melhora nos aspectos social e emocional de 0 a 6 meses, enquanto GI se associou a melhora significativa em estado geral de saúde e aspecto social de 0 a 6 meses, com tendência de melhora até 0 a 12 meses. Nas lesões do uterossacro, não houve relações significativas entre tipo histológico e qualidade de vida, e o trabalho limita-se ao seguimento por 12 meses e ao recorte de GI/GM para as análises. This paper is centrally about endometriosis — it evaluates how histologic differentiation (GI vs GM) in biopsies relates to SF-36 quality-of-life changes after laparoscopic surgery for deep endometriosis.

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Abstract

PURPOSE: To assess the relationship between the histological classification and the quality of life of patients operated for endometriosis. METHODS: A cross-sectional observational study, with assessment of 32 biopsies of the intestine, peritoneum and uterosacral ligament from 40 women with deep endometriosis. The quality of life (QOL) was determined by applying the SF-36 questionnaire pre-operatively and at 6 and 12 months postoperatively. Biopsies were histologically classified into pure stromal (EP), glandular differentiated (GD), glandular undifferentiated (GI) and mixed (GM), remaining in the sample only GI and GM, which are related to eight domains of the SF-36. RESULTS: According to the histologic type, the following distribution was observed: peritoneum 63% GI and 35% GM; intestine 19% GI and 24% GM; uterosacral ligament with 41% GI and 35% GM. Regarding the QOL and the histological classification, in the intestine only GM was associated with improvement of social and emotional aspects from 0 to 6 months; the domains general health status (p=0.01) and social aspect (p=0.04) were significantly related to improvement of the QOL from 0 to 6 months, and the general health status tended to improve from 0 to 12 months. Regarding pain (p=0.06) and the emotional aspect (p=0.05), the QOL tended to improve from 0 to 6 months and the vital capacity (p=0.1) improved from 0 to 6 months and from 0 to 12 months. Regarding the emotional aspect, evolution of the two histological types was not favorable for improvement in MG from 0 to 6 months. No significant relationships between histologic type and QOL were evident in the uterosacral ligament samples. CONCLUSION: Improvement in the QOL of women undergoing laparoscopic surgery for deep endometriosis is associated with the histologic grade. The peritoneal biopsy of GI revealed improved QOL after surgery.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Intestinal Diseases Peritoneal Diseases Quality of Life Adult Cross-Sectional Studies Endometriosis Endometriosis Female Humans Intestinal Diseases Intestinal Diseases Peritoneal Diseases Peritoneal Diseases Pilot Projects

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (31)

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