Clinical aspects and the quality of life among women with endometriosis and infertility: a cross-sectional study

Marina Pessoa de Farias Rodrigues, Fabia Lima Vilarino, Fabia Lima Vilariño, Alessandra de Souza Barbeiro Munhoz, Laércio da Silva Paiva, Luiz Vinicius de Alcantara Sousa, Luiz Vinícius de Alcantara Sousa, Victor Zaia, Caio Parente Barbosa
BMC women's health · 2020 · vol. 20(1) , pp. 124 · doi:10.1186/s12905-020-00987-7 · PMID:32532273 · PMC7291762 · W3034384396
article OA: gold CC0 ⤵ 35 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

Quality of life in women with endometriosis and infertility is determined by clinical symptoms like pain and dyspareunia, not disease stage.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This cross-sectional observational study assessed quality of life using the SF-36 in 106 infertile women with laparoscopy-confirmed endometriosis recruited from a specialized outpatient clinic in São Paulo, Brazil, comparing ASRM stage I/II versus stage III/IV and relating QoL domain scores to clinical symptoms such as dyspareunia and various pain types. The authors found no meaningful differences in age, infertility characteristics, degree of pain, or common endometriosis symptoms across staging groups, and they reported significant associations between symptom characteristics (notably dyspareunia and pain outside menstruation) and specific SF-36 domains including physical functioning, role-emotional, general health, and role-physical. A key caveat is that the study relied on convenience sampling from a single clinic and used a generic QoL instrument, which may not capture endometriosis-specific dimensions. This paper is centrally about endometriosis — it examines how clinical manifestations and infertility relate to quality of life across endometriosis staging in infertile women.

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Abstract

BACKGROUND: The quality of life (QoL) of patients with endometriosis and infertility was assessed in different stages and correlated with the clinical features of the cases. METHODS: The present study was a cross-sectional study; 106 women were included, divided in two endometriosis groups (Grade I/II, 26 women, and Grade II/IV, 74 women). All participants attended the Endometriosis and Infertility Outpatient Clinic of the Instituto Ideia Fértil de Saúde Reprodutiva, Faculdade de Medicina do ABC, São Paulo, Brazil, were and responded to the Short Form (SF) Health Survey-36. Convenience sampling was used due to the authors' access to the study population; however, the sample number was calculated to be sufficient for 95% power in both groups. RESULTS: Homogeneity was observed between Grade I/II and Grade III/IV staging, with similar mean ages (35.27, ±3.64 years and 34.04, ±3.39 years, respectively, p = 0.133); types of infertility (p = 0.535); infertility time (p = 0.654); degrees of pain (p = 0.849); and symptoms common to endometriosis, namely, dysmenorrhea (p = 0.841), dyspareunia (0.466), chronic pelvic pain (p = 0.295), and intestinal (p = 0.573) or urinary (p = 0.809) diseases. Comparisons of median scores in the QoL domains demonstrated that the distributions of QoL and clinical symptoms were significantly related between the types of dyspareunia and the following domains: physical functioning (p = 0.017), role- emotional (p = 0.013), and general health (p = 0.001). Regarding pain outside of menstruation, there was significance in the pain domain (p = 0.017), and degree of pain was significance in physical functioning (p = 0.005) and role-physical (p = 0.011) domains. CONCLUSIONS: The present study pointed out that it is not the stage of endometriosis that interferes in the quality of life of women with endometriosis and infertility but rather the clinical manifestations, such as dyspareunia and pain. Thus, we can conclude that the patient's perception of the disease should be considered in health care and that the losses are independent of the degree of endometriosis in this population with the aggravating factor of infertility.

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Condition tags

dysmenorrheadyspareuniaendometriosischronic_pelvic_paininfertility

MeSH descriptors

Depression Dysmenorrhea Dyspareunia Endometriosis Infertility, Female Pelvic Pain Quality of Life Adult Brazil Brazil Cross-Sectional Studies Depression Depression Dysmenorrhea Dysmenorrhea Dyspareunia Dyspareunia Endometriosis Endometriosis Endometriosis

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