Comparing the quality of life of endometriotic patients' before and after treatment with normal and infertile patients based on the EHP30 questionnaire

Tahereh Poordast, Saeed Alborzi, Elham Askary, Malihe Sousani Tavabe, Fatemeh Sadat Najib, Alireza Salehi, Hossein Molavi Vardanjani, Neda Haghighat, Kimia Leilami
BMC women's health · 2022 · vol. 22(1) , pp. 553 · doi:10.1186/s12905-022-02052-x · PMID:36577953 · PMC9795634 · W4312215589
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

Endometriosis and infertility significantly reduce quality of life, with infertile women reporting the lowest scores, and endometriosis treatment, especially surgical, improves quality of life.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-09 ⓘ

This prospective comparative study enrolled 400 premenopausal women (100 each in endometriosis without infertility, endometriosis with infertility, healthy women, and infertile women without endometriosis) and used the EHP-30 disease-specific quality-of-life questionnaire plus a visual analog scale for pain at baseline and again 3 months after medical or surgical treatment in the endometriosis-without-infertility group. Mean quality of life scores were significantly lower in the endometriosis ± infertility groups and the infertile-only control group than in healthy women, with the lowest scores in infertile women and better scores associated with older age and higher education within groups; pain scores decreased sharply after treatment, and surgical treatment produced greater QOL improvement than medical treatment. Limitations included convenience sampling and diagnosis of endometriosis via clinical symptoms confirmed by transvaginal ultrasound. This paper is centrally about endometriosis — it evaluates EHP-30 quality-of-life and pain changes before and after treatment in endometriotic patients and contrasts these with women with or without infertility.

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Abstract

OBJECTIVE: This study aimed to determine the quality of life (QOL), in patients with endometriosis ± infertility (B and C groups) and compare those to healthy women, and also infertile groups without endometriosis as a control groups (A and D), considering the fact that endometriosis and infertility reduces the quality of life in patients. METHODS: The present prospective comparative study was carried out between January 2018 and September 2020. A total of 400 women were included (100 women in each group). The participants filled in a validated questionnaire of quality of life, Endometriosis Health Profile-30 (EHP-30), and a visual analog scale of pain used, at the first visit, and 3 months after the medical or surgical treatment in the endometriosis group without infertility, additionally. RESULTS: The majority of the patients were married, categorized in the middle-class of socio-economic state and housewives. They were of Persian descent. BMI was high in the infertile groups; however, the time of infertility was not different between the two groups of B and C (P = 0.054). The mean score of QOL was significantly lower in B, C, and D groups in comparison to the healthy women as the control group (A) (P < 0.001). Moreover, the infertile group (B), in comparison to endometriosis ± infertility groups (C and D), had the lowest mean score of QOL (P < 0.001). In each group, those who were older and had better educational level reported a better quality of life than other participants in that group. Social support plays a very important role in reducing the endometriosis related pain symptoms both before and after treatment. Three months after the treatment of endometriosis (D), a significant improvement was observed in all the aspects of QOL-related endometriosis. Nonetheless, the improvement of the quality of life in the surgical group was significantly higher than that in the medical treatment. The mean visual analog score of pain decreased from 62.22 ± 22.78, to 5.15 ± 2.73 following the surgical treatment (P < 0.001). CONCLUSION: The lowest quality of life belonged to the infertile group, followed by the endometriosis group. The quality of life of the endometriosis group improved after the treatment. Thus, endometriotic patients' treatment in terms of improvement of quality of life should be considered by all professional health care teams.

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Outcome instruments

EHP-30

Condition tags

endometriosischronic_pelvic_paininfertility

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Infertility, Female Infertility, Female Infertility, Female Infertility, Female Infertility, Female

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