Clinical factors associated with quality of life among women with endometriosis: a cross-sectional study

Karin Pontoppidan, K. Pontoppidan, Matts Olovsson, Hanna Grundström
BMC women's health · 2023 · vol. 23(1) , pp. 551 · doi:10.1186/s12905-023-02694-5 · PMID:37875883 · PMC10594903 · W4387906118
article OA: gold CC0 ⤵ 8 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This study found that younger age at symptom onset, mental health issues, and opioid use were associated with worse quality of life in women with endometriosis, while patient-centeredness was associated with better quality of life.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This cross-sectional national study surveyed 476 Swedish women diagnosed with endometriosis using the disease-specific Endometriosis Health Profile-30 (EHP-30) to measure quality of life (QoL) and the EndoCare Questionnaire to quantify patient-centeredness, then used univariate and multivariable regression to test associations between clinical factors and overall QoL and QoL dimensions. The participants reported low QoL, and multivariable analyses found significant correlations with worse overall QoL for earlier age at first endometriosis symptom onset, having more than 10 general-practitioner visits before referral to a gynecologist, current or previous mental health issues, and opioid use, while higher patient-centeredness was associated with better QoL. The paper notes that the association between opioid use and worse QoL may reflect underlying symptom severity and mental health rather than opioid use itself. This paper is centrally about endometriosis — it analyzes clinical factors associated with QoL in women with endometriosis.

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Abstract

BACKGROUND: Endometriosis often leads to a decrease in Quality of Life (QoL), due to its impact on various aspects of women's lives, such as social life, mental health, sex life, and working capacity. Although previous studies have assessed QoL in women with endometriosis, few studies have explored the impact of different clinical variables on QoL. The aim of this study was to investigate how women with endometriosis perceive their QoL, and to analyze which clinical factors are associated with QoL. METHODS: The Endometriosis Health Profile-30 and the ENDOCARE Questionnaire were distributed to 1000 women diagnosed with endometriosis from 10 different clinics across Sweden. The responses from 476 women were included in univariate and multivariable regression analyses, where the clinical factors were correlated with overall QoL and QoL dimensions. RESULTS: The women participating in this study reported a low QoL. The clinical factors that showed a significant correlation with overall QoL were age at first onset of endometriosis symptoms (β= -0.64, p < 0.001), having more than 10 visits to general practitioners before referral to a gynecologist (β = 5.58, p = 0.036), current or previous mental health issues (β = 7.98, p < 0.001) patient-centeredness (β= -2.59, p < 0.001) and use of opioids (β = 7.14, p = 0.002). CONCLUSIONS: This study shows that opioid use and mental health issues were associated with a worse QoL, whereas a higher degree of patient-centeredness was associated with a better QoL. The association between opioid use and a worse QoL might not entirely be caused by the opioid use itself but also by symptom severity and mental health issues. An improved patient-centeredness and more focus on taking care of mental health issues would reasonably result in a better QoL for women with endometriosis.

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Outcome instruments

EHP-30

Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Quality of Life Quality of Life Quality of Life Quality of Life Quality of Life Analgesics, Opioid Analgesics, Opioid Analgesics, Opioid Analgesics, Opioid Cross-Sectional Studies Cross-Sectional Studies Cross-Sectional Studies Cross-Sectional Studies Female Female

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References (27)

Cited by (9)

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License: CC0 · commercial use OK