Nerve Growth Factor Is Associated With Sexual Pain in Women With Endometriosis

Bo Peng, Hong Zhan, Fahad Alotaibi, Fahad T. Alotaibi, Ghadeer M Alkusayer, Mohamed A Bedaiwy, Paul J Yong
Reproductive sciences (Thousand Oaks, Calif.) · 2017 · vol. 25(4) , pp. 540–549 · doi:10.1177/1933719117716778 · PMID:28673205 · W2780337009
article OA: closed CC0 ⤵ 36 in-corpus citations
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-08 ⓘ

Nerve growth factor (NGF) and its receptor TrkA were elevated in endometriosis lesions from women with deep dyspareunia, and NGF increased COX-2 and PGE2 in cultured cells.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-10 ⓘ

The study examined nerve growth factor (NGF) and its receptors (TrkA and p75NTR) in surgically excised cul-de-sac/uterosacral endometriosis from 32 women with endometriosis, comparing those with deep dyspareunia versus those without using immunohistochemistry and Histoscore blinded to pain phenotype. NGF immunointensity and TrkA were significantly elevated in endometriotic stroma and epithelium in women with deep dyspareunia, while p75NTR was not, and NGF in stroma was associated with both deep dyspareunia intensity and local nerve bundle density; however, the receptor and tissue-expression analyses were cross-sectional and based on a relatively small posterior-compartment cohort. In cultured endometriotic stromal cells, NGF increased PTGS-2/COX-2 expression and PGE2 secretion, and these effects were blocked by the Trk inhibitor K252a. This paper is centrally about endometriosis — specifically linking NGF/TrkA signaling and COX-2/PGE2 activity to endometriosis-associated deep dyspareunia.

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Condition tags

mesh:D004414mesh:D004715mesh:D017699endometriosis

MeSH descriptors

Dyspareunia Endometriosis Nerve Growth Factor Peritoneal Diseases Receptor, Nerve Growth Factor Receptor, trkA Dyspareunia Dyspareunia Endometriosis Endometriosis Female Humans Nerve Growth Factor Pelvic Pain Pelvic Pain Pelvic Pain Peritoneal Diseases Peritoneal Diseases Receptor, Nerve Growth Factor Receptor, trkA

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License: CC0 · commercial use OK