Nerve Bundle Density and Expression of NGF and IL-1β Are Intra-Individually Heterogenous in Subtypes of Endometriosis

Mahfuza Sreya, Dwayne Tucker, Jennifer Y. Yi, Jennifer Yi, Fahad T Alotaibi, Anna F. Lee, Heather Noga, Paul J. Yong
Biomolecules · 2024 · vol. 14(5) , pp. 583 · doi:10.3390/biom14050583 · PMID:38785989 · W4396937915
article OA: gold CC0 ⤵ 2 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This study found that nerve bundle density, nerve growth factor (NGF), and interleukin-1β (IL-1β) expression are heterogeneously distributed across different endometriosis subtypes within individual patients.

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Abstract

Endometriosis is a gynecological disorder associated with local inflammation and neuroproliferation. Increased nerve bundle density has been attributed to increased expression of nerve growth factor (NGF) and interleukin-1β (IL-1β). Immunohistochemical analysis was carried out on 12 patients presenting with all three anatomic subtypes of endometriosis (deep, superficial peritoneal, endometrioma) at surgery, with at least two surgically excised subtypes available for analysis. Immunolocalization for nerve bundle density around endometriosis using protein gene product 9.5 (PGP9.5), as well as NGF and IL-1β histoscores in endometriosis epithelium/stroma, was performed to evaluate differences in scores between lesions and anatomic subtypes per patient. Intra-individual heterogeneity in scores across lesions was assessed using the coefficient of variation (CV). The degree of score variability between subtypes was evaluated using the percentage difference between mean scores from one subtype to another subtype for each marker. PGP9.5 nerve bundle density was heterogenous across multiple subtypes of endometriosis, ranging from 50.0% to 173.2%, where most patients (8/12) showed CV ≥ 100%. The percentage difference in scores showed that PGP9.5 nerve bundle density and NGF and IL-1β expression were heterogenous between anatomic subtypes within the same patient. Based on these observations of intra-individual heterogeneity, we conclude that markers of neuroproliferation in endometriosis should be stratified by anatomic subtype in future studies of clinical correlation.

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Condition tags

mesh:D004715endometriosisendometrioma

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Interleukin-1beta Interleukin-1beta Interleukin-1beta Interleukin-1beta Interleukin-1beta Interleukin-1beta Interleukin-1beta Interleukin-1beta Nerve Growth Factor Nerve Growth Factor Nerve Growth Factor

Citation neighborhood

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Cited by (3)

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