Endometriosis-targeted MRI imaging using bevacizumab-modified nanoparticles aimed at vascular endothelial growth factor

Qi Zhang, Shiman Wu, Yajie Li, Mao Lai, M. Lai, Qing Li, Caixia Fu, Zhenwei Yao, Junhai Zhang
Nanoscale advances · 2023 · vol. 5(15) , pp. 3994–4001 · doi:10.1039/d2na00787h · PMID:37496625 · PMC10367955 · W4381664950
article OA: gold CC0 ⤵ 1 in-corpus citation
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

Bevacizumab-modified nanoparticles were used for MRI imaging of endometriosis, targeting vascular endothelial growth factor and showing effective endometriosis targeting three days post-injection.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-10 ⓘ

The paper developed an endometriosis-targeted MRI contrast agent by modifying NaGdF4@PEG nanoparticles with bevacizumab (NaGdF4@PEG@bevacizumab–Cy5.5, NPBCNs) to target enriched vascular endothelial growth factor (VEGF) in endometriosis. In vitro, NPBCNs showed negligible cytotoxicity and high affinity for VEGF in endometrial cells, and in vivo they produced strong T1-weighted MRI signal enhancement in endometriosis lesions in rats at 3 days after injection, supported by histopathology and fluorescence imaging. The study is reported as preclinical (rats and cell assays) and is framed as a case for improved imaging-based diagnosis rather than providing human diagnostic performance data. This paper is centrally about endometriosis — it presents VEGF-targeted bevacizumab-modified nanoparticles for MRI detection of endometriosis lesions.

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Abstract

MRI at 3 days post-injection, as confirmed by the histopathological staining results and fluorescence imaging on the same day. Our approach can enable NPBCNs to target endometriosis effectively, thus avoiding missed diagnoses.

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endometriosis

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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