Oxytocin receptor expression in smooth muscle cells of peritoneal endometriotic lesions and ovarian endometriotic cysts

Sylvia Mechsner, Julia Bartley, Bartley J, Loddenkemper C, Christoph Loddenkemper, Salomon DS, David S. Salomon, Anna Starzinski-Powitz, Anna Starzinski‐Powitz, Starzinski-Powitz A, Ebert AD, Andreas D. Ebert
Fertility and sterility · 2005 · vol. 83(4) , pp. 1220–1231 · doi:10.1016/j.fertnstert.2004.11.038 · PMID:15831296 · W1997612119
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This study investigated oxytocin receptor expression within the smooth muscle cells of peritoneal endometriotic lesions and ovarian endometriotic cysts.

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Abstract

ObjectiveTo investigate the expression of oxytocin receptor (OTR) in peritoneal and ovarian endometriotic lesions.DesignRetrospective nonrandomized study.SettingUniversity hospital endometriosis research center.Patient(s)Premenopausal women with histologically confirmed endometriosis were selected. Peritoneal endometriotic lesions (n = 120); ovarian endometriotic cysts (n = 40); peritoneal biopsies, distant from the endometriotic lesion (n = 55); and unaffected peritoneal biopsies from patients without endometriosis (n = 11) were obtained. Hysterectomy specimens from patients without endometriosis and/or adenomyosis were used for controls (n = 10).Intervention(s)Histopathological examination of peritoneal and ovarian specimens for OTR expression and identification of smooth muscle cells by immunohistochemistry staining with antibodies against OTR and smooth muscle actin. In addition, Western blot analysis, double-immunofluorescence, and in vitro studies with primary cell cultures have been performed.Main outcome measure(s)Comparison of the immunoreactive score of the OTR and smooth muscle actin expression with the smooth muscle content in peritoneum with and without endometriosis.Result(s)In the epithelial cells of endometriotic lesions, we could demonstrate a high OTR expression. The stromal cells were OTR negative with the exception of some single cells. By using a monoclonal anti-smooth muscle actin antibody, these cells could be identified as intrastromal OTR-positive smooth muscle cells. The peritoneum of women with endometriosis shows a significantly higher smooth muscle content than the peritoneum of women without endometriosis. There were no significant differences between the smooth muscle content of active or inactive lesions and the stage of disease.Conclusion(s)Oxytocin receptor is expressed in smooth muscle cells and epithelial cells of peritoneal endometriotic lesions and ovarian endometriotic cysts. The inhibition of OTR by specific inhibitors might be a useful approach for the treatment of endometriosis-associated pain.

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MeSH descriptors

Endometrium Myocytes, Smooth Muscle Ovarian Cysts Peritoneum Receptors, Oxytocin Adult Blotting, Western Endometrium Endometrium Female Fluorescent Antibody Technique Humans Metaplasia Middle Aged Myocytes, Smooth Muscle Myocytes, Smooth Muscle Myometrium Myometrium Myometrium Ovarian Cysts

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