Endometriosis occurring in leiomyomatosis peritonealis disseminata

Tseng-tong Kuo, Kuo T, T Kuo, London SN, S N London, Steve N. London, T V Dinh, Tung Van Dinh, Dinh TV
The American journal of surgical pathology · 1980 · vol. 4(2) , pp. 197–204 · doi:10.1097/00000478-198004000-00012 · PMID:7377465 · W1970312454
article OA: closed CC0 ⤵ 13 in-corpus citations
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-10 ⓘ

This report describes a new case of leiomyomatosis peritonealis disseminata, a benign condition mimicking abdominal carcinoma, and discusses its possible histogenesis from metaplasia of subcoelomic mesenchyme, potentially influenced by endometriosis.

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This case report examines a patient with leiomyomatosis peritonealis disseminata, a rare benign condition characterized by multiple peritoneal nodules composed of smooth-muscle cells. The authors utilized electron microscopy to confirm the histological nature of these lesions and noted the concurrent presence of endometriosis in the same patient. While serum estrogen levels were normal, the study favors a theory of metaplasia from subcoelomic mesenchyme as the underlying pathogenesis, suggesting an unusual sensitivity of coelomic tissues to metaplastic stimuli. This paper is centrally about endometriosis — specifically its concurrent occurrence with leiomyomatosis peritonealis disseminata, which aids in discussing the histogenetic considerations of both conditions.

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Abstract

Leiomyomatosis peritonealis disseminata is a pseudomalignant condition which mimics disseminated abdominal carcinoma. A new case is reported and compared to the 11 well-documented cases in the literature. All reported patients have experienced a benign clinical course. The peritoneal nodules are composed of histologically benign-appearing smooth-muscle cells, substantiated by electron-microscopic study. The histogenesis of this entity is discussed in the light of our ultrastructural findings and the observation of concurrent endometriosis. The theory of metaplasia of the subcoelomic mesenchyme in the pathogenesis of the leiomyomatous lesions is favored. The serum estrogen levels determined in our patient did not reveal any abnormal change. The inducing factor(s) remain to be identified. Also, an unusual sensitivity of the coelomic tissues in these patients, in response to metaplastic stimuli, is postulated as a possible contributing factor.
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Endometriosis occurring in leiomyomatosis peritonealis disseminata Ultrastructural study and histogenetic consideration - Tseng-tong Kuo - Steve N. London - Tung V. Dinh Leiomyomatosis peritonealis disseminata is a pseudomalignant condition which mimics disseminated abdominal carcinoma. A new case is reported and compared to the 11 well-documented cases in the literature. All reported patients have experienced a benign clinical course. The peritoneal nodules are composed of histologically benign-appearing smooth-muscle cells, substantiated by electron-microscopic study. The histogenesis of this entity is discussed in the light of our ultrastructural findings and the observation of concurrent endometriosis. The theory of metaplasia of the subcoelomic mesenchyme in the pathogenesis of the leiomyomatous lesions is favored. The serum estrogen levels determined in our patient did not reveal any abnormal change. The inducing factor(s) remain to be identified. Also, an unusual sensitivity of the coelomic tissues in these patients, in response to metaplastic stimuli, is postulated as a possible contributing factor.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Leiomyoma Peritoneal Neoplasms Adult Endometriosis Endometriosis Endometriosis Female Humans Leiomyoma Leiomyoma Leiomyoma Omentum Omentum Peritoneal Neoplasms Peritoneal Neoplasms Peritoneal Neoplasms

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