Phosphatase of regenerating liver-3: a novel and promising marker in human endometriosis

Ruan F, Fei Ruan, Lin J, Jun Lin, Wu RJ, Rui-Jin Wu, Ruijin Wu, Xu KH, Kaihong Xu, Kai-Hong Xu, Xinmei Zhang, Xin-Mei ZHANG, Zhang XM, Zhou CY, Caiyun Zhou, Cai-yun Zhou, Xiu-feng Huang, Xiufeng Huang
Fertility and sterility · 2010 · vol. 94(6) , pp. 1980–1984 · doi:10.1016/j.fertnstert.2009.10.065 · PMID:20045518 · W2112318220
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This paper investigates Phosphatase of regenerating liver-3 (PRL-3) as a potential new marker for human endometriosis.

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Abstract

ObjectiveTo investigate the expression of phosphatase of regenerating liver-3 (PRL-3) in ectopic, eutopic, and normal endometria and explore its relationship with endometriosis.DesignA clinical retrospective and molecular study.SettingDepartment of obstetrics, gynecology, and reproductive medicine.Patient(s)One hundred and five women with histopathologically confirmed endometriosis, and 50 women with histopathologically assessed normal endometria.Intervention(s)Immunohistochemical staining and Western blot analysis.Main outcome measure(s)Expression of PRL-3 protein.Result(s)As shown by the immunohistochemical analysis, PRL-3 was mainly located in the cytoplasm and membrane. The cells that tested positive for PRL-3 were detected in endometriotic tissues that did not occur in eutopic and normal endometria. Statistical analysis indicated that the expression of PRL-3 was closely associated with the clinical stages and recurrence of endometriosis.Conclusion(s)Expression of PRL-3 is related to the clinical stages and recurrence of endometriosis, which provides use with a novel marker and promising target in the treatment of human endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Neoplasm Proteins Protein Tyrosine Phosphatases Uterine Diseases Adult Biomarkers Biomarkers Biomarkers Blotting, Western Endometriosis Endometriosis Endometriosis Female Humans Immunohistochemistry Middle Aged Neoplasm Proteins Neoplasm Proteins Protein Tyrosine Phosphatases Protein Tyrosine Phosphatases

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