Laparoscopic extensive myomectomy, hysterectomy for large myomas, laparoscopic treatment of endometriosis or treatment of cancer of the uterus are advanced laparoscopic gynaecological procedures. Since they can be very challenging, many spe…
The appropriate surgical technique to treat patients with uterine fibroids is still a matter of debate as is the potential risk of incorrect treatment if histological examination detects a uterine sarcoma instead of uterine fibroids. The pu…
Fragestellung: Die Aerosolplasma-Koagulation (AePC) stellt eine neue Variante der bekannten APC- (Argon-Plasma-Koagulation) Methode dar, wobei das Prinzip in der Koagulation von biologischem Gewebe durch Plasmaanwendung besteht. Bei der Aer…
BACKGROUND: Endometriosis as a benign disease appears frequently in premenopausal women with highly variable symptoms. In advanced stages bowel involvement is common. In symptomatic disease the adequate treatment requires complete resection…
Introduction: Quality reporting was initially implemented to offer a better means of assessing hospitals and to provide patients with information to help them when choosing their hospital. Quality reports are published every 2 years and inc…
Patients are expected to be increasingly competent about health issues, and patient self-determination is on the rise. This makes it ever more necessary to provide high quality information which is increasingly being offered to patients at …
Introduction: The German DRG system is annually adapted to the changing services provided. For the further development, the self-governing body and its DRG Institute (InEK) depend on participation of the users. Methods: For one of the DRG e…
Fragestellung: Tiefe infiltrierende Endometriose erfordert ein der individuellen Situation angepasstes radikales Vorgehen. Während des letzten Jahrzehnts hat sich hier ein operativer Wandel weg von der Laparatomie hin zum Laparoskopischen Z…
Die Endometriose ist eine der häufigsten benignen gynäkologischen Erkrankungen der geschlechtsreifen Frau. Die Ausprägung kann von kleinen oberflächlichen Herden bis zur Infiltration in das Rektum und bis zum Befall der Ureteren beidseits f…
Einleitung: Die Rolle von Östrogenrezeptor beta (ERß) in der Pathogenese der Endometriose wird in der Literatur zunehmend diskutiert. Ziel unserer Arbeit ist es, neben der Expression von ERα die zyklische Expression von ERß und v.a. seiner …
We explored the association of the PPAR-gamma2 (peroxisome proliferator-activated receptor) Pro-12-Ala polymorphism with endometriosis in a case-control study with 51 women with endometriosis stages I-IV and 55 control women without endomet…
Die Behandlung der Endometriose konzentriert sich auf zwei Hauptziele: die Verringerung von Schmerzen und die Therapie der Infertilität. Die Schmerztherapie bei Endometriose wurde bisher gut untersucht. So waren alle medikamentösen Behandlu…
Eine erhöhte Anzahl von aktivierten Peritonealmakrophagen, die durch Chemokine angezogen werden, sind ein wichtiges pathophysiologisches Merkmal für Frauen mit Endometriose. In dieser Studie charakterisieren wir die inflammatorische Antwort…
Chemoattraction of macrophages into the peritoneal cavity is one of the important characteristics in patients with endometriosis. An inflammatory response is postulated to be responsible for infertility and pelvic pain associated with this …
OBJECTIVES: Changes in estradiol metabolism may play a role in the pathophysiology of different diseases, of special interest being an increase in D-ring over A-ring metabolites for the risk of breast cancer. In the present work we investig…
Die Migration von Makrophagen in die Peritonealhöhle ist ein wesentlicher pathophysiologischer Faktor der Endometriose. Frühere Daten aus unserem Labor deuteten darauf hin, dass RANTES (Regulated on Activation, Normal T cell Expressed and S…
Endometriotic lesions secrete chemokines that recruit immune cells into the peritoneal cavity. The accumulation of these immune cells, especially activated macrophages and T lymphocytes, is thought to mediate inflammatory symptoms associate…
OBJECTIVES: Aim was to compare the effects of estradiol-only therapy with combined estradiol/progestin treatment on the excretion of vasoactive mediators surrogating on possible effects in the vascular system. The progestin used was dienoge…
The peroxisome proliferator-activated receptors (PPARs) alpha and gamma are nuclear receptors that play important roles in inflammatory diseases like ulcerative colitis and arthritis. In this study, we examined the possible role of PPARs in…
Chemoattraction of macrophages and T cells into the normal endometrium and inflammatory sites within endometriotic foci is mediated by chemokine gene expression. mRNA transcripts encoding regulated on activation, normal T-cell-expressed and…
OBJECTIVE: In the present study the effect of two contraceptive pills, i.e. Neorlest, containing ethinylestradiol and norethisterone acetate, and Valette, containing ethinylestradiol and the new progestin dienogest, was investigated on the …
Our laboratories have focused recently on the production and localization of eotaxin, a C-C-chemokine of 8.4 kDa, whose major biological activity is the chemoattraction of eosinophils. Given evidence of autoimmune activity in the endometrio…
The assessment of the activity of endometriosis provides a challenge during endoscopic procedures. Novel approaches can be developed in future based on more detailed understanding of the mechanisms of the pathogenesis of endometriosis. Angi…
The assessment of the activity of endometriosis provides a challenge during endoscopic procedures. Novel approaches can be developed in future based on more detailed understanding of the mechanisms of the pathogenesis of endometriosis. Angi…