D. Wallwiener

Laparoscopic extensive myomectomy, hysterectomy for large myomas, laparoscopic treatment of endometriosis or treatment of cancer of the uterus are advanced laparoscopic gynaecological procedures. Since they can be very challenging, many spe…

Fragestellung: Die Aerosolplasma-Koagulation (AePC) stellt eine neue Variante der bekannten APC- (Argon-Plasma-Koagulation) Methode dar, wobei das Prinzip in der Koagulation von biologischem Gewebe durch Plasmaanwendung besteht. Bei der Aer…

BackgroundEndometriosis as a benign disease appears frequently in premenopausal women with highly variable symptoms. In advanced stages bowel involvement is common. In symptomatic disease the adequate treatment requires complete resection o…

Fragestellung: Tiefe infiltrierende Endometriose erfordert ein der individuellen Situation angepasstes radikales Vorgehen. Während des letzten Jahrzehnts hat sich hier ein operativer Wandel weg von der Laparatomie hin zum Laparoskopischen Z…

Die Endometriose ist eine der häufigsten benignen gynäkologischen Erkrankungen der geschlechtsreifen Frau. Die Ausprägung kann von kleinen oberflächlichen Herden bis zur Infiltration in das Rektum und bis zum Befall der Ureteren beidseits f…

Einleitung: Die Rolle von Östrogenrezeptor beta (ERß) in der Pathogenese der Endometriose wird in der Literatur zunehmend diskutiert. Ziel unserer Arbeit ist es, neben der Expression von ERα die zyklische Expression von ERß und v.a. seiner …

We explored the association of the PPAR-gamma2 (peroxisome proliferator-activated receptor) Pro-12-Ala polymorphism with endometriosis in a case-control study with 51 women with endometriosis stages I-IV and 55 control women without endomet…

Die Behandlung der Endometriose konzentriert sich auf zwei Hauptziele: die Verringerung von Schmerzen und die Therapie der Infertilität. Die Schmerztherapie bei Endometriose wurde bisher gut untersucht. So waren alle medikamentösen Behandlu…

Eine erhöhte Anzahl von aktivierten Peritonealmakrophagen, die durch Chemokine angezogen werden, sind ein wichtiges pathophysiologisches Merkmal für Frauen mit Endometriose. In dieser Studie charakterisieren wir die inflammatorische Antwort…

Chemoattraction of macrophages into the peritoneal cavity is one of the important characteristics in patients with endometriosis. An inflammatory response is postulated to be responsible for infertility and pelvic pain associated with this …

ObjectivesChanges in estradiol metabolism may play a role in the pathophysiology of different diseases, of special interest being an increase in D-ring over A-ring metabolites for the risk of breast cancer. In the present work we investigat…

Die Migration von Makrophagen in die Peritonealhöhle ist ein wesentlicher pathophysiologischer Faktor der Endometriose. Frühere Daten aus unserem Labor deuteten darauf hin, dass RANTES (Regulated on Activation, Normal T cell Expressed and S…

Endometriotic lesions secrete chemokines that recruit immune cells into the peritoneal cavity. The accumulation of these immune cells, especially activated macrophages and T lymphocytes, is thought to mediate inflammatory symptoms associate…

ObjectivesAim was to compare the effects of estradiol-only therapy with combined estradiol/progestin treatment on the excretion of vasoactive mediators surrogating on possible effects in the vascular system. The progestin used was dienogest…

The peroxisome proliferator-activated receptors (PPARs) alpha and gamma are nuclear receptors that play important roles in inflammatory diseases like ulcerative colitis and arthritis. In this study, we examined the possible role of PPARs in…

Chemoattraction of macrophages and T cells into the normal endometrium and inflammatory sites within endometriotic foci is mediated by chemokine gene expression. mRNA transcripts encoding regulated on activation, normal T-cell-expressed and…

Our laboratories have focused recently on the production and localization of eotaxin, a C-C-chemokine of 8.4 kDa, whose major biological activity is the chemoattraction of eosinophils. Given evidence of autoimmune activity in the endometrio…

The assessment of the activity of endometriosis provides a challenge during endoscopic procedures. Novel approaches can be developed in future based on more detailed understanding of the mechanisms of the pathogenesis of endometriosis. Angi…

The assessment of the activity of endometriosis provides a challenge during endoscopic procedures. Novel approaches can be developed in future based on more detailed understanding of the mechanisms of the pathogenesis of endometriosis. Angi…

ObjectiveTo compare formation of adhesions after injury to both parietal and visceral peritoneum and to determine the benefit of autologous transplants and alloplastic barriers in adhesion prevention.DesignExperimental prospective animal st…

A hysteroscopic endometrial ablation (HEA) under maximal anesthesiologic surveillance was performed on 34 high-risk patients (group I: chronic anticoagulant therapy n = 26; group II: endogenous coagulopathy n = 8) with therapy resistant men…

Hysteroscopic endometrial ablation under maximal anaesthesiological surveillance was performed in 34 high-risk patients to avoid hysterectomy. It was a collective of patients with heavy thrombo-embolic or thrombotic disease, either under pe…

A comparative study on thermal, mainly laser and high frequency electrosurgical techniques, was conducted. Indications, handling and morphometric results were correlated. Morphometrical findings suggest that minimal thermal tissue damage is…