Peroxisome proliferator-activated receptor γ agonist suppresses human telomerase reverse transcriptase expression and aromatase activity in eutopic endometrial stromal cells from endometriosis

Hye Jin Chang, Jae Hoon Lee, Kyung Joo Hwang, Mee‐Ran Kim, Mi Ran Kim, Jung Hyun Yoo
Clinical and experimental reproductive medicine · 2013 · vol. 40(2) , pp. 67 · doi:10.5653/cerm.2013.40.2.67 · PMID:23875162 · PMC3714431 · W2123402995
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Peroxisome proliferator-activated receptor γ agonist suppressed human telomerase reverse transcriptase and aromatase expression, along with proliferation, in endometriosis stromal cells.

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Abstract

OBJECTIVE: To investigate the effect of peroxisome proliferator activated receptor γ (PPARγ) agonist on the cell proliferation properties and expression of human telomerase reverse transcriptase (hTERT) and aromatase in cultured endometrial stromal cell (ESC) from patients with endometriosis. METHODS: Human endometrial tissues were obtained from women with endometriosis and healthy women (controls) using endometrial biopsy. Isolated ESCs were cultured and the cell proliferation was measured by 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide assay and expression of hTERT, aromatase, and cyclooxygenase (COX)-2 by western blotting according to the addition of rosiglitazone (PPARγ agonist). RESULTS: We demonstrate that the cultured ESCs of endometriosis showed hTERT protein overexpression and increased cellular proliferation, which was inhibited by rosiglitazone, in a dose-dependent manner. At the same time, PPARγ agonist also inhibited aromatase and COX-2 expression, resulting in decreased prostaglandin E2 production in the ESCs of endometriosis. CONCLUSION: This study suggests that PPARγ agonist plays an inhibitory role in the proliferative properties of eutopic endometrium with endometriosis by down-regulation of hTERT and COX-2 expression; this could be a new treatment target for endometriosis.

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Condition tags

endometriosis

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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organisms 28
human human human human human human human human transgenic mice rabbits naine d'afrique de l'ouest naine d'afrique de l'ouest naine d'afrique de l'ouest horseradish transgenic mice rabbits human human rodents zitter rats zitter rats papio papio sensu groves transgenic mice rodents mus sp. mus sp. alphacoronavirus 2 humans
chemicals 55
bromide rosiglitazone rosiglitazone prostaglandins e estrogen estrogen prostaglandin rosiglitazone rosiglitazone estrogen rosiglitazone prostaglandins e rosiglitazone penicillin streptomycin rosiglitazone rosiglitazone rosiglitazone rosiglitazone bromide dimethyl ethynylboronate sodium sulfate polyacrylamide macromolecule nitrocellulose rosiglitazone estrogen prostaglandin rosiglitazone rosiglitazone phytochelatin 2 rosiglitazone rosiglitazone rosiglitazone rosiglitazone rosiglitazone rosiglitazone rosiglitazone rosiglitazone rosiglitazone estrogen prostaglandin estrogen estrogen estrogen estradiol estradiol estradiol rosiglitazone rosiglitazone rosiglitazone ciglitazone rosiglitazone pioglitazone rosiglitazone rosiglitazone

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