Thiazolidinedione inhibition of peritoneal inflammation

Hornung D, Daniela Hornung, Victor A. Chao, Chao Va, Jean‐Louis Vigne, Jean-Louis Vigne, Vigne JL, Diethelm Wallwiener, Wallwiener D, D. Wallwiener, Robert N. Taylor, Taylor RN
Gynecologic and obstetric investigation · 2003 · vol. 55(1) , pp. 20–24 · doi:10.1159/000068952 · PMID:12624547 · W2035351560
Lab / animal OA: closed CC0 ⤵ 23 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-07 ⓘ

Thiazolidinediones like ciglitazone inhibited macrophage infiltration and pro-inflammatory cytokine secretion in a murine model of peritoneal inflammation.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Chemoattraction of macrophages into the peritoneal cavity is one of the important characteristics in patients with endometriosis. An inflammatory response is postulated to be responsible for infertility and pelvic pain associated with this syndrome. The present in vivo studies were designed to test if thiazolidinediones (TZDs), activators of peroxisome proliferator activated receptor gamma, could inhibit monocyte chemotaxis in a murine model. TZDs were first used as orally bioavailable insulin-sensitizing agents. They are currently under investigation in the treatment of inflammatory diseases, including arthritis or colitis. Intraperitoneal injection of thioglycollate was used to elicit high numbers of activated peritoneal macrophages in female mice. Concomitant peritoneal injection of ciglitazone, a member of the TZD family, significantly reduced the number of macrophages. When cultured and stimulated by tumor necrosis factor alpha, these peritoneal macrophages also secreted less RANTES and less IL-1beta protein. This animal model suggests that treatment of endometriosis patients with TZDs may diminish symptoms associated with intraperitoneal inflammation.

My notes (saved in your browser only)

Condition tags

endometriosisinfertility

MeSH descriptors

Endometriosis Peroxisome Proliferators Thiazoles Thiazolidinediones Thiazolidinediones Animals Animals Chemokine CCL5 Chemokine CCL5 Chemokine CCL5 Disease Models, Animal Disease Models, Animal Endometriosis Endometriosis Endometriosis Female Female Interleukin-1 Interleukin-1 Interleukin-1

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (25)

Cited by (22)

Source provenance

europepmc
last seen: 2026-10-12T06:17:10.165071+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-10-08T21:00:58.458861+00:00
unpaywall
last seen: 2026-10-12T06:33:14.382917+00:00
License: CC0 · commercial use OK