Entstehung und Pathogenese

In: Endometriose · 2004 · pp. 1–35 · doi:10.1007/978-3-7091-0574-0_1 · W954731152
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Endometriosis is an estrogen-dependent disease characterized by endometrial-like tissue found outside the uterine cavity, requiring a stromal component for hormone responsiveness.

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This paper discusses the concept and pathogenesis of endometriosis, defining it as estrogen-dependent, benign endometrium-like tissue found outside the uterine cavity, and emphasizing that a stromal component is a key prerequisite for hormonal responsiveness. It frames endometriosis as an ectopic manifestation derived from endometrial tissue rather than a disorder of endometrium confined to the uterus. A limitation is that the provided text is largely definitional and mechanistic in overview, without describing specific empirical study methods or data from a study population. This paper is centrally about endometriosis — it focuses on the origin and pathogenesis, including ectopic endometrial tissue and estrogen-dependent hormonal responsiveness requiring stromal components.

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Zusammenfassung Der Begriff der Endometriose leitet sich vom Endometrium ab. Dabei handelt es sich um endomeriumähnliches Gewebe, welches ektop, also nicht im Cavum uteri zu finden ist. Die Endometriose ist eine östrogenabhängige, benigne Erkrankung. Das Vorhandensein einer stromatalen Komponente ist eine wichtige Voraussetzung für die hormoneile Ansprechbarkeit. Preview Unable to display preview. Download preview PDF. Similar content being viewed by others Literatur AFS (1979) Classification of endometriosis. The American Fertility Society. Fertil Steril 32: 633–634 AFS (1997) Revised American Society for Reproductive Medicine classification of endometriosis: 1996. Fertil Steril 67: 817–821 Attia GR, Zeitoun K, Edwards D, Johns A, Carr BR, Bulun SE (2000) Progesterone receptor isoform A but not B is expressed in endometriosis. J Clin Endocrinol Metab 85: 2897–2902 Badawy SZ, Marshall L, Cuenca V (1985) Peritoneal fluid prostaglandins in various stages of the menstrual cycle: role in infertile patients with endometriosis. Int J Fertil 30: 48–52 Badawy SZ, Marshall L, Gabal AA, Nusbaum ML (1982) The concentration of 13,14-dihydro-15-keto prostaglandin F2 alpha and prostaglandin E2 in peritoneal fluid of infertile patients with and without endometriosis. Fertil Steril 38: 166–170 Ballweg ML (2003) Tips on treating teens with endometriosis. J Pediatr Adolesc Gynecol 16: S27–28 Barbieri RL, Niloff JM, Bast RC Jr, Scaetzl E, Kistner RW, Knapp RC (1986) Elevated serum concentrations of CA-125 in patients with advanced endometriosis. Fertil Steril 45: 630–634 Berglund AS, Sparén P, Bergqvist A (2003) Endometriosis and the risk of cancer. 19th ESHRE Annual Meeting xviii: 80 Bergqvist A, Ljungberg O, Skoog L (1993) Immunohistochemical analysis of oestrogen and progesterone receptors in endometriotic tissue and endometrium. Hum Reprod 8: 1915–1922 Busacca M, Bianchi S, Agnoli B, Candiani M, Calia C, De Marinis S, Vignali M (1999) Follow-up of laparoscopic treatment of stage III-IV endometriosis. J Am Assoc Gynecol Laparosc 6: 55–58 Buttram VC Jr (1979) Conservative surgery for endometriosis in the infertile female: a study of 206 patients with implications for both medical and surgical therapy. Fertil Steril 31: 117–123 Candiani GB, Fedele L, Vercellini P, Bianchi S, Di Nola G (1991) Repetitive conservative surgery for recurrence of endometriosis. Obstet Gynecol 77: 421–424 Cramer DW, Wilson E, Stillman RJ, Berger MJ, Belisle S, Schiff I, Albrecht B, Gibson M, Stadel BV, Schoenbaum SC (1986) The relation of endometriosis to menstrual characteristics, smoking, and exercise. Jama 255: 1904–1908 Cust MP, Gangar KF, Hillard TC, Whitehead MI (1990) A risk-benefit assessment of estrogen therapy in postmenopausal women. Drug Saf 5: 345–358 Czernobilsky B, Morris WJ (1979) A histologic study of ovarian endometriosis with emphasis on hyperplastic and atypical changes. Obstet Gynecol 53: 318–323 Czernobilsky B, Silverman BB, Enterline HT (1970a) Clear-cell carcinoma of the ovary. A clinicopathologic analysis of pure and mixed forms and comparison with endometrioid carcinoma. Cancer 25: 762–772 Czernobilsky B, Silverman BB, Mikuta JJ (1970b) Endometrioid carcinoma of the ovary. A clinicopathologic study of 75 cases. Cancer 26: 1141–1152 Dabrosin C, Gyorffy S, Margetts P, Ross C, Gauldie J (2002) Therapeutic effect of angiostatin gene transfer in a murine model of endometriosis. Am J Pathol 161: 909–918 De Placido G, Alviggi C, Di Palma G, Carravetta C, Matarese G, Landino G, Racioppi L (1998) Serum concentrations of soluble human leukocyte class I antigens and of the soluble intercellular adhesion molecule-1 in endometriosis: relationship with stage and non-pigmented peritoneal lesions. Hum Reprod 13: 3206–3210 Donnez J, Squifflet J, Pirard C, Jadoul P, Wyns C, Smets M (2002) The efficacy of medical and surgical treatment of endometriosis-associated infertility and pelvic pain. Gynecol Obstet Invest 54Suppl 1: 2–10 Eskenazi B, Mocarelli P, Warner M, Samuels S, Vercellini P, Olive D, Needham L, Patterson D, Brambilla P (2000) Seveso Women's Health Study: a study of the effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on reproductive health. Chemosphere 40: 1247–1253 Falcone T, Goldberg JM, Miller KF (1996) Endometriosis: medical and surgical intervention. Curr Opin Obstet Gynecol 8: 178–183 Foster WG (2003) Do environmental contaminants adversely affect human reproductive physiology? J Obstet Gynaecol Can 25: 33–44 Gazvani R, Templeton A (2002) Peritoneal environment, cytokines and angiogenesis in the pathophysiology of endometriosis. Reproduction 123: 217–226 Groll M (1984) Endometriosis and spontaneous abortion. Fertil Steril 41: 933–935 Halme J, Hammond MG, Hulka JF, Raj SG, Talbert LM (1984) Retrograde menstruation in healthy women and in patients with endometriosis. Obstet Gynecol 64: 151–154 Harada T, Yoshioka H, Yoshida S, Iwabe T, Onohara Y, Tanikawa M, Terakawa N (1997) Increased interleukin-6 levels in peritoneal fluid of infertile patients with active endometriosis. Am J Obstet Gynecol 176: 593–597 Hirschowitz JS, Soler NG, Wortsman J (1978) The galactorrhoea-endometriosis syndrome. Lancet 1: 896–898 Hornung D, Chao VA, Vigne JL, Wallwiener D, Taylor RN (2003) Thiazolidinedione inhibition of peritoneal inflammation. Gynecol Obstet Invest 55: 20–24 Hornung D, Ryan IP, Chao VA, Vigne JL, Schriock ED, Taylor RN (1997) Immunolocalization and regulation of the chemokine RANTES in human endometrial and endometriosis tissues and cells. J Clin Endocrinol Metab 82: 1621–1628 Hull ML, Charnock-Jones DS, Chan CL, Bruner-Tran KL, Osteen KG, Tom BD, Fan TP, Smith SK (2003) Antiangiogenic agents are effective inhibitors of endometriosis. J Clin Endocrinol Metab 88: 2889–2899 Inan S, Kuscu NK, Vatansever S, Ozbilgin K, Koyuncu F, Sayhan S (2003) Increased vascular surface density in ovarian endometriosis. Gynecol Endocrinol 17: 143–150 Kammerer-Doak DN, Magrina JF, Nemiro JS, Lidner TK (1996) Benign gynecologic conditions associated with a CA-125 level > 1,000 U/mL. A case report. J Reprod Med 41: 179–182 Kauppila A, Vierikko P, Isotalo H, Ronnberg L, Vihko R (1984) Cytosol estrogen and progestin receptor concentrations and 17 beta-hydroxysteroid dehydrogenase activities in the endometrium and endometriotic tissue. Effects of hormonal treatment. Acta Obstet Gynecol Scand Suppl 123: 45–49 Kayisli UA, Mahutte NG, Arici A (2002) Uterine chemokines in reproductive physiology and pathology. Am J Reprod Immunol 47: 213–221 Kitawaki J, Kado N, Ishihara H, Koshiba H, Kitaoka Y, Honjo H (2002) Endometriosis: the pathophysiology as an estrogen-dependent disease. J Steroid Biochem Mol Biol 83: 149–155 Kiyan E, Kilicaslan Z, Caglar E, Yilmazbayhan D, Tabak L, Gurgan M (2002) An unusual radiographic finding in pulmonary parenchymal endometriosis. Acta Radiol 43: 164–166 Koninckx PR, Kennedy SH, Barlow DH (1998) Endometriotic disease: the role of peritoneal fluid. Hum Reprod Update 4: 741–751 Kühn W, Staemmler H, Neckel E (1981) Endometriose — Implantation oder Metaplasie? Geb Fra 41: 698 Küpker W, Felberbaum R, Bauer O, Diedrich K (1996) [Significance of tumor necrosis factor alpha (TNF-alpha) in endometriosis]. Geburtshilfe Frauenheilkd 56: 239–242 Küpker W, Schultze-Mosgau A, Diedrich K (1998) Paracrine changes in the peritoneal environment of women with endometriosis. Hum Reprod Update 4: 719–723 Lu PY, Ory SJ (1995) Endometriosis: current management. Mayo Clin Proc 70: 453–463 Magtibay PM, Heppell J, Leslie KO (2001) Endometriosis-associated invasive adenocarcinoma involving the rectum in a postmenopausal female: report of a case. Dis Colon Rectum 44: 1530–1533 Mathur S, Peress MR, Williamson HO, Youmans CD, Maney SA, Garvin AJ, Rust PF, Fudenberg HH (1982) Autoimmunity to endometrium and ovary in endometriosis. Clin Exp Immunol 50: 259–266 McLaren J (2000) Vascular endothelial growth factor and endometriotic angiogenesis. Hum Reprod Update 6: 45–55 Meyer R (1919) Über den Stand der Frage der Adenomyosistis und Adenomyome im allgemeinen und insbesondere über Adenomyosistis seroepithelialis und Adenomyometritis sarcomatosa. Zentralbl Gynäkol 43: 745–750 Muse K, Wilson EA, Jawad MJ (1982) Prolactin hyperstimulation in response to thyrotropin-releasing hormone in patients with endometriosis. Fertil Steril 38: 419–422 Naples JD, Batt RE, Sadigh H (1981) Spontaneous abortion rate in patients with endometriosis. Obstet Gynecol 57: 509–512 Ortmann O, Catt KJ, Schulz KD, Emons G (1994) Modulatory action of progesterone and progesterone antagonists on hypothalamic-pituitary function. Hum Reprod 9 [Suppl 1]: 53–62 Pal L, Shifren JL, Isaacson KB, Chang Y, Leykin L, Toth TL (1998) Impact of varying stages of endometriosis on the outcome of in vitro fertilization-embryo transfer. J Assist Reprod Genet 15: 27–31 Pellicer A, Albert C, Garrido N, Navarro J, Remohi J, Simon C (2000) The pathophysiology of endometriosis-associated infertility: follicular environment and embryo quality. J Reprod Fertil Suppl 55: 109–119 Ramey JW, Archer DF (1993) Peritoneal fluid: its relevance to the development of endometriosis. Fertil Steril 60: 1–14 Reynolds LP, Grazul-Bilska AT, Redmer DA (2002) Angiogenesis in the female reproductive organs: pathological implications. Int J Exp Pathol 83: 151–163 Ridley JH (1966) Primary adenocarcinoma in implant of endometriosis. Obstet Gynecol 27: 261–267 Rier SE, Coe CL, Lemieux AM, Martin DC, Morris R, Lucier GW, Clark GC (2001) Increased tumor necrosis factor-alpha production by peripheral blood leukocytes from TCDD-exposed rhesus monkeys. Toxicol Sci 60: 327–337 Rier SE, Martin DC, Bowman RE, Dmowski WP, Becker JL (1993) Endometriosis in rhesus monkeys (Macaca mulatta) following chronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Fundam Appl Toxicol 21: 433–441 Ronnberg L, Kauppila A, Rajaniemi H (1984) Luteinizing hormone receptor disorder in endometriosis. Fertil Steril 42: 64–68 Saltiel E, Garabedian-Ruffalo SM (1991) Pharmacologic management of endometriosis. Clin Pharm 10: 518–531 Sampson JA (1925) Heterotopic or misplaced endometrial tissue. Am J Obstet Gynecol 10: 649–664 Sampson JA (1927) Peritoneal endometriosis due to menstrual dissemination of enddometrial tissue into peritoneal cavity. Am J Obstet Gynecol 14: 422 Schmidt CL (1985) Endometriosis: a reappraisal of pathogenesis and treatment. Fertil Steril 44: 157–173 Simpson JL, Elias S, Malinak LR, Buttram VC, Jr. (1980) Heritable aspects of endometriosis. I. Genetic studies. Am J Obstet Gynecol 137: 327–331 Stratton P, Winkel CA, Sinaii N, Merino MJ, Zimmer C, Nieman LK (2002) Location, color, size, depth, and volume may predict endometriosis in lesions resected at surgery. Fertil Steril 78: 743–749 Suginami H (1991) A reappraisal of the coelomic metaplasia theory by reviewing endometriosis occurring in unusual sites and instances. Am J Obstet Gynecol 165: 214–218 Suginami H, Yano K, Watanabe K, Matsuura S (1986) A factor inhibiting ovum capture by the oviductal fimbriae present in endometriosis peritoneal fluid. Fertil Steril 46: 1140–1146 Taylor RN, Lebovic DI, Mueller MD (2002) Angiogenic factors in endometriosis. Ann NY Acad Sci 955: 89–100; discussion 118, 396-406 Terada Y, Chen F, Shoji T, Itoh H, Wada H, Hitomi S (1999) A case of endobronchial endometriosis treated by subsegmentectomy. Chest 115: 1475–1478 Thibodeau LL, Prioleau GR, Manuelidis EE, Merino MJ, Heafner MD (1987) Cerebral endometriosis. Case report. J Neurosurg 66: 609–610 Waller KG, Shaw RW (1993) Gonadotropin-releasing hormone analogues for the treatment of endometriosis: long-term follow-up. Fertil Steril 59: 511–515 Weed JC, Arquembourg PC (1980) Endometriosis: can it produce an autoimmune response resulting in infertility? Clin Obstet Gynecol 23: 885–893 Wheeler JM, Johnston BM, Malinak LR (1983) The relationship of endometriosis to spontaneous abortion. Fertil Steril 39: 656–660 Wu MY, Ho HN (2003) The role of cytokines in endometriosis. Am J Reprod Immunol 49: 285–296 Yoshida K, Ikeda S, Nakanishi J (2000) Assessment of human health risk of dioxins in Japan. Chemosphere 40: 177–185 Author information Authors and Affiliations Rights and permissions Copyright information © 2004 Springer-Verlag Wien About this chapter Cite this chapter Finas, D., Küpker, W., Diedrich, K., Felberbaum, R. (2004). Entstehung und Pathogenese. In: Endometriose. Springer, Vienna. https://doi.org/10.1007/978-3-7091-0574-0_1 Download citation DOI: https://doi.org/10.1007/978-3-7091-0574-0_1 Publisher Name: Springer, Vienna Print ISBN: 978-3-7091-7196-7 Online ISBN: 978-3-7091-0574-0 eBook Packages: Springer Book Archive

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