Endometriose - Implantation oder Metaplasie?

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This review examines endometriosis theories and cases, proposing that ovarian endometriosis arises from coelomic epithelium metaplasia, particularly in genital malformations, rather than implantation.

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This paper reviews competing theories, hypotheses, localizations, and experimental evidence for how uterine and extrauterine endometriosis develops, concluding that no single etiologic mechanism explains all locations and that different theories may be required depending on where ectopic endometrial tissue is found. It presents a case of a young woman with Mayer-Rokitansky-Küster syndrome (congenital vaginal aplasia with a rudimentary uterus bicornis solidus) combined with ovarian endometriosis. Because the rudimentary uterus lacks functional endometrium, the author argues that several proposed routes (e.g., canalicular spread, hematogenous/lymphogenous routes, embolic/metastatic mechanisms, or homotransplantation) are excluded for this scenario. The paper asserts that ovarian endometrial heterotopia arises instead from pluripotentiality of coelomic epithelium via indentation and segmentation. This paper is centrally about endometriosis—specifically ovarian endometriosis in the context of a genital malformation syndrome and a mechanistic “implantation versus metaplasia” argument.

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Abstract

The article deals with the various theories, hypotheses, localisations and experiments in connection with the genesis of uterine and extrauterine endometriosis. It is explained that there is not just one single valid cause; rather, it will be necessary to resort to various theories, depending on the localisation of the endometrial heterotopia. The article describes the case of a young woman with genital malformation combined with ovarial endometriosis. This malformation syndrome is known as Mayer-Rokitansky-Küster syndrome with congenital aplasia of the vagina and a rudimentary uterus bicornis solidus. Since such uteri do not contain any endometrium which is capable of functioning, this would exclude any canalicular, haematogenic, lymphogenic, embolic, metastatic or homotransplantational cause of endometriosis. In fact, ovarial endometrial tissue heterotopia is due to pluropotentiality of the coelomic epithelium and is produced by indentation of cortical epithelium and segmentation.
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Subscribe to RSS DOI: 10.1055/s-2008-1037319 © Georg Thieme Verlag Stuttgart · New York Endometriose - Implantation oder Metaplasie? Ein kasuistischer Beitrag zur Histo- und Pathogenese unter besonderer Berücksichtigung der OvarialendometrioseEndometriosis - Implantation or Metaplasie?Publication History Publication Date: 19 March 2008 (online) Zusammenfassung Die Ausführungen beschäftigen sich mit den verschiedenen Theorien, Hypothesen, Lokalisationen und Experimenten zur Entstehung der uterinen und extrauterinen Endometriose. Es wird dargelegt, daß nicht eine einzige gültige Entstehungsursache existiert, sondern je nach Lokalisation der endometrialen Heterotopien verschiedene Theorien bemüht werden müssen. Es wird berichtet über eine junge Frau mit einer genitalen Mißbildung, die kombiniert ist mit einer Ovarialendometriose. Es handelt sich bei dem Mißbildungssyndrom um ein Mayer-Rokitansky-Küster-Syndrom, das neben einer Vaginalaplasie einen Uterus bicornis solidus rudimentarius beinhaltet. Da derartige Uteri kein funktionstüchtiges Endometrium enthalten, scheidet pathogenetisch eine kanalikuläre, hämatogene, lymphogene, embolische, metastatische oder homotransplantatische Entstehung der Endometriose aus. Die ovarielle endometriale Gewebsheterotopie ist vielmehr Folge einer Pluripotenz des Zölomepithels und vollzieht sich durch Einkerbungen von Rindenepithel und Abschnürung. Abstract The article deals with the various theories, hypotheses, localisations and experiments in connection with the genesis of uterine and extrauterine endometriosis. It is explained that there is not just one single valid cause; rather, it will be necessary to resort to various theories, depending on the localisation of the endometrial heterotopia. The article describes the case of a young woman with genital malformation combined with ovarial endometrosis. This malformation syndrome is known as Mayer-Rokitansky-Küster syndrome with congential aplasia of the vagina and a rudimentary uterus bicornis solidus. Since such uteri do not contain any endometrium which is capable of functioning, this would exclude any canalicular, haematogenic, lymphogenic, embolic, metastatic or homotransplantational cause of endometriosis. In fact, ovarial endometrial tissue heterotopia is due to pluropotentiality of the coelomic epithelium and is produced by indentation of cortical epithelium and segmentation.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Ovarian Neoplasms Adolescent Endometriosis Endometriosis Female Humans Ovarian Neoplasms Ovarian Neoplasms Syndrome Uterus Uterus Vagina Vagina

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