Endometriose - Implantation oder Metaplasie?
This review examines endometriosis theories and cases, proposing that ovarian endometriosis arises from coelomic epithelium metaplasia, particularly in genital malformations, rather than implantation.
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This paper reviews competing theories, hypotheses, localizations, and experimental evidence for how uterine and extrauterine endometriosis develops, concluding that no single etiologic mechanism explains all locations and that different theories may be required depending on where ectopic endometrial tissue is found. It presents a case of a young woman with Mayer-Rokitansky-Küster syndrome (congenital vaginal aplasia with a rudimentary uterus bicornis solidus) combined with ovarian endometriosis. Because the rudimentary uterus lacks functional endometrium, the author argues that several proposed routes (e.g., canalicular spread, hematogenous/lymphogenous routes, embolic/metastatic mechanisms, or homotransplantation) are excluded for this scenario. The paper asserts that ovarian endometrial heterotopia arises instead from pluripotentiality of coelomic epithelium via indentation and segmentation. This paper is centrally about endometriosis—specifically ovarian endometriosis in the context of a genital malformation syndrome and a mechanistic “implantation versus metaplasia” argument.
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- europepmc
- last seen: 2026-06-11T06:19:48.454388+00:00
- openalex
- last seen: 2026-06-04T00:00:01.174412+00:00
- pubmed
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