PAPP-A and osteoprotegerin, together with interleukin-8 and RANTES, are elevated in the peritoneal fluid of women with endometriosis

Nick A. Bersinger, Bersinger NA, von Roten S, Stéphanie von Roten, Wunder DM, Dorothea M Wunder, Dorothea Wunder, Luigi Raio, Raio L, Ekkehard Dreher, E. Dreher, Dreher E, Michael D. Mueller
American journal of obstetrics and gynecology · 2006 · vol. 195(1) , pp. 103–108 · doi:10.1016/j.ajog.2005.12.010 · PMID:16635455 · W2085124613
Other OA: closed CC0 ⤵ 59 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-08 ⓘ

This study found elevated levels of PAPP-A, osteoprotegerin, interleukin-8, and RANTES in the peritoneal fluid of women diagnosed with endometriosis.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

OBJECTIVE: The purpose of this study was to evaluate whether pregnancy-associated plasma protein A, glycodelin, osteoprotegerin, and soluble CD163 are possible peritoneal fluid markers for endometriosis and to compare them with the established chemokine markers interleukin-8 and regulated on activation, normal T-cell expressed and secreted. STUDY DESIGN: Determination of the concentrations of interleukin-8, regulated on activation, normal T-cell expressed and secreted, pregnancy-associated plasma protein A, glycodelin, CD163, osteoprotegerin, and progesterone in the peritoneal fluid collected from women undergoing laparoscopy. RESULTS: From a total of 132 women, 77 women were diagnosed with endometriosis, and 55 women were free of the disease and served as control subjects. Pregnancy-associated plasma protein A and osteoprotegerin showed significantly (P < 0.05) elevated peritoneal fluid concentrations as a function of the severity of the disease, together with interleukin-8 and regulated on activation, normal T-cell expressed and secreted (P < .001). Glycodelin and CD163 did not differ between cases and control subjects. Many of these marker concentrations were intercorrelated strongly. CONCLUSION: Pregnancy-associated plasma protein A and osteoprotegerin may play a role in the inflammation process of endometriosis, but interleukin-8 and regulated on activation, normal T-cell expressed and secreted are superior peritoneal fluid markers.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Ascitic Fluid Chemokine CCL5 Endometriosis Glycoproteins Interleukin-8 Pregnancy-Associated Plasma Protein-A Receptors, Cytoplasmic and Nuclear Receptors, Tumor Necrosis Factor Adult Adult Ascitic Fluid Ascitic Fluid Chemokine CCL5 Chemokine CCL5 Endometriosis Endometriosis Female Female Glycoproteins Glycoproteins

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (23)

Cited by (50)

Source provenance

europepmc
last seen: 2026-10-09T06:09:53.026058+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-10-08T21:03:44.483075+00:00
unpaywall
last seen: 2026-10-09T06:36:44.367587+00:00
License: CC0 · commercial use OK