Dienogest in women with persistent endometriosis-related pelvic pain during norethisterone acetate treatment

Matteo Morotti, F. Sozzi, Fausta Sozzi, Valentino Remorgida, Pier Luigi Venturini, Venturini PL, Simone Ferrero
European journal of obstetrics, gynecology, and reproductive biology · 2014 · vol. 183 , pp. 188–192 · doi:10.1016/j.ejogrb.2014.10.036 · PMID:25461377 · W1971584256
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This study investigated dienogest's efficacy for persistent endometriosis-related pelvic pain in women already being treated with norethisterone acetate.

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Abstract

ObjectiveTo evaluate patient satisfaction at 6-months dienogest (DNG) treatment in women with symptomatic rectovaginal endometriosis who had pain persistence and were unsatisfied after 6-months of norethisterone acetate (NETA) therapy.Study designThis 24-weeks pilot open-label prospective study enrolled 25 women. The main outcome was the degree of patient satisfaction measured by using a Likert scale. Secondary outcomes were to evaluate differences in endometriosis-related pain, quality of life, sexual function changes and volumetric nodules changes during DNG compared to NETA treatment.ResultsPatient satisfaction improved at 3- and 6-months (p<0.001, respectively) treatment with DNG compared with baseline treatment with NETA. Six months DNG treatment decreased the intensity of all the endometriosis-associated pain (chronic pelvic pain, dyspareunia, dyschezia) compared to baseline (p<0.001 for all comparisons). Quality of life and quality of sexual life evaluated with the EHP-30 and FSFI, respectively, increased after 6 months treatment. The volume of the endometriotic nodules did not significantly change during treatment.ConclusionsThis study confirms the efficacy of DNG in treating symptomatic women with rectovaginal endometriosis even in a particular endometriotic subpopulation of NETA "resistant" patients. Further randomized clinical trials comparing these two progestins both in first than second line are warranted.

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Condition tags

endometriosischronic_pelvic_pain

MeSH descriptors

Contraceptives, Oral Endometriosis Nandrolone Norethindrone Pelvic Pain Rectal Diseases Vaginal Diseases Adult Contraceptives, Oral Endometriosis Endometriosis Female Follow-Up Studies Humans Nandrolone Nandrolone Norethindrone Norethindrone Norethindrone Acetate Pain Measurement

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