The Therapeutic Role of Dienogest in Endometriosis-Associated Pain: From Basics to Clinics

Ying Yan, Xi Lan, Huaxi Mai, Hao Tan, Y I X I U Liang
In: Biomolecules · 2026 · vol. 16(8) , pp. 1080 · doi:10.3390/biom16081080 · W7170195877
article OA: gold CC0
🔓 Open OA copy View on OpenAlex View at publisher
⚙ AI-generated summary by claude@2026-07, 2026-07-28 ⓘ

This review examines how dienogest alleviates endometriosis-associated pain by impacting nerve fiber distribution, central sensitization, inflammation, hypoxia, and endometriotic stromal cells, and highlights its clinical efficacy and safety.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

The most common symptom of endometriosis is pain. The pathogenesis of endometriosis-associated pain remains unclear. In this review, we illustrate the pathogenesis of endometriosis-associated pain and the mechanisms of dienogest acts on endometriosis-associated pain, as well as therapeutic applications targeting these processes, by searching the literature in PubMed and Web of Science until May 2026. Abnormal distribution of nerve fibers, central sensitization, imbalance of inflammatory and immune environment, and hypoxic stress contribute to the generation of endometriosis-associated pain. Dienogest, as a fourth-generation selective progesterone receptor agonist, plays a key role in the treatment of endometriosis-associated pain by reducing serum estrogen levels, alleviating inflammatory responses, regulating nerve growth factor, modulating control central nervous system allergies, and influencing the biological processes of endometriotic stromal cells. Moreover, its long-term safety and tolerability are relatively satisfactory according to clinical studies, making it an effective therapeutic agent for endometriosis.

My notes (saved in your browser only)

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (85)

Source provenance

openalex
last seen: 2026-07-29T06:19:52.536310+00:00
License: CC0 · commercial use OK