Effect of aromatase inhibitor (letrozole) with long agonist protocol on the results of ICSI/ET in females with minimal and mild endometriosis

Mohamed S. Abd Rabbo, Hassan Ali Hassan Elmaghraby, Nagwa Mashali, Mohamed E. Abdel Moneim
In: Alexandria Journal of Medicine · 2012 · vol. 48(4) , pp. 303–307 · doi:10.1016/j.ajme.2012.04.001 · W1982084639
article OA: closed CC0 ⤵ 1 in-corpus citation
View on OpenAlex View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

Letrozole added to a long agonist protocol for ICSI/ET in women with minimal/mild endometriosis increased stimulation days without affecting pregnancy rates.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

BackgroundICSI/ET in endometriosis patients has poor outcome by traditional protocols. The key enzyme in the biosynthesis of estradiol, aromatase, has been demonstrated within endometriosis. Combined administration of aromatase inhibitor and GnRH-agonist may efficiently suppress estrogen biosynthesis through a combined pituitary, ovarian and local factors in the implants.ObjectiveEvaluate the effect of using letrozole in improvement of the results of ICSI/ET in endometriosis women with long agonist protocol.PatientsSixty infertile women with minimal and mild endometriosis according to the revised American Fertility Society classification were scheduled for ICSI/ET.MethodsWomen were randomized into two groups. Group 1: using the traditional luteal long agonist protocol using triptorelin 0.1 and Group 2: using letrozole 5 mg/day started 5 days after the start of GnRH agonist for 5 days. All patients were monitored with day 6 serum estradiol level and estradiol at day of HCG. The number of days of stimulation, number of retrieved oocytes, number of MII oocytes, cleavage rate, and pregnancy rate were studied in both groups.ResultsDays of stimulation were significantly higher in the treated group (p = 0.019). Oocytes number was not affected (10.57 ± 6.14) and (11.21 ± 6.41) (p = 0.516) in groups 1 and 2 respectively also, the number of embryos was not affected (p = 0.955). Nine (32.1%) pregnant cases of 28 were in the first group while 8 from 27 in the second group (29.6%).ConclusionLetrozole significantly affected days of stimulation of ICSI cycle in endometriosis patients without affecting pregnancy rate.

My notes (saved in your browser only)

Condition tags

endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (19)

Cited by (1)

Source provenance

openalex
last seen: 2026-06-10T17:14:06.276822+00:00
License: CC0 · commercial use OK