Increased monocyte chemotactic protein-1 level and activity in the peripheral blood of women with endometriosis

Ali Akoum, Akoum A, A Akoum, Lemay A, A Lemay, André Lemay, McColl SR, S R McColl, Shaun R. McColl, Paradis I, I Paradis, Isabelle Paradis, Rodolphe Maheux, R Maheux, Maheux R
American Journal of Obstetrics and Gynecology · 1996 · vol. 175(6) , pp. 1620–1625 · doi:10.1016/s0002-9378(96)70115-1 · PMID:8987950 · W1994914920
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This study investigated monocyte chemotactic protein-1 (MCP-1) levels and activity in the peripheral blood of women with endometriosis, finding increased levels and activity compared to controls.

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Abstract

ObjectiveOur purpose was to evaluate monocyte chemotactic protein-1 in the peripheral blood of women with and without endometriosis.Study designFifty-seven patients with endometriosis at laparoscopy done for infertility and pelvic pain were compared with 44 fertile women with no evidence of endometriosis at tubal ligation by laparoscopy. Monocyte chemotactic protein-1 concentration in the plasma was determined by enzyme-linked immunosorbent assay and its biologic activity was evaluated by measuring monocyte chemotaxis with use of a human histiocytic cell line (U937).ResultsMonocyte chemotactic protein-1 concentrations (median and range of values) found in the plasma were higher in patients with endometriosis (163, 0 to 788 pg/ml) than in normal controls (0, 0 to 355 pg/ml). This elevation was significant only in the minimal stage of endometriosis (revised American Fertility Society stage I). However, increased chemotactic activity (mean number of migrating cells/mm2 +/- SEM) was found in the stages I (1240 +/- 141), II (519 +/- 30), and III-IV (523 +/- 23) of the disease compared with normal controls (205 +/- 20). A total of 35% to 44% of this activity was inhibited in the presence of an antibody specific to monocyte chemotactic protein-1.ConclusionEndometriosis is associated with increased level and activity of monocyte chemotactic protein-1 in the peripheral blood. The elevation and activation of this cytokine could play a relevant role in the immunoinflammatory process associated with the disease.

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Condition tags

endometriosis

MeSH descriptors

Chemokine CCL2 Endometriosis Adult Cell Line Chemokine CCL2 Chemotaxis Endometriosis Endometriosis Enzyme-Linked Immunosorbent Assay Female Humans Monocytes Monocytes Osmolar Concentration Reference Values

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