The stimulus responsible for the peritoneal fluid inflammation observed in infertile women with endometriosis

A F Haney, Haney AF, Jenkins S, S. Jenkins, Susan L. Jenkins, Weinberg JB, J B Weinberg, Jason B. Weinberg
Fertility and sterility · 1991 · vol. 56(3) , pp. 408–413 · doi:10.1016/s0015-0282(16)54532-4 · PMID:1894017 · W2401848375
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This paper investigates the specific stimulus that causes peritoneal fluid inflammation in infertile women diagnosed with endometriosis.

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Abstract

ObjectiveWe tested the hypothesis that menstrual debris from ectopic endometrium is the stimulus responsible for eliciting the peritoneal fluid (PF) inflammation observed in infertile women with endometriosis.Design, setting, patientsThe extent of endometriosis was correlated with the PF volume and total PF cell count retrospectively in 135 infertile women with endometriosis.ResultsThe volume and total cell count were positively correlated, whereas the total cell count was negatively correlated with the extent of endometriosis. Despite a similar negative trend, no statistically significant correlation was noted between the volume and the extent of endometriosis. These relationships did not change when the data were reanalyzed deleting those pathological features contributing to the endometriosis score but not capable of producing intraperitoneal menstrual debris, i.e., adhesions and encapsulated ovarian endometriomas.ConclusionsThese findings indicate that menstrual debris from ectopic endometrium is probably not a major factor in the elicitation of the observed PF inflammation in infertile women with endometriosis and suggest an inverse relationship may exist between PF inflammation and the extent of endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Ascitic Fluid Endometriosis Infertility, Female Ascitic Fluid Cell Count Endometriosis Endometriosis Female Humans Infertility, Female Infertility, Female Inflammation Inflammation Menstrual Cycle Regression Analysis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (32)

Cited by (36)

Source provenance

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License: CC0 · commercial use OK