Evaluation of monocyte chemotactic protein-1 levels in peripheral blood of infertile women with endometriosis

Gmyrek GB, Grzegorz B. Gmyrek, Rafał Sozański, Rafal Sozanski, Sozanski R, Małgorzata Jerzak, Jerzak M, Malgorzata Jerzak, Agnieszka Chrobak, Dorota Wickiewicz, Wickiewicz D, Alicja Skupnik, Skupnik A, Sieradzka U, Urszula Sieradzka, Wojciech Fortuna, M Gabryś, Marian Gabrys, Anna Chełmońska‐Soyta, Chelmonska-Soyta A, Anna Chelmonska-Soyta
European journal of obstetrics, gynecology, and reproductive biology · 2005 · vol. 122(2) , pp. 199–205 · doi:10.1016/j.ejogrb.2005.03.019 · PMID:15893866 · W1998424234
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This study measured monocyte chemotactic protein-1 levels in the peripheral blood of infertile women with endometriosis.

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Abstract

OBJECTIVE: To test whether serum monocyte chemotactic protein-1 (MCP-1) chemokine levels correlate with endometriosis in infertile women. STUDY DESIGN: A group of women with endometriosis (n = 18, infertile) was compared with patients with uterine leiomyoma (n = 16, fertile), unexplained infertility (n = 5, infertile), and healthy women (n = 16, fertile). MCP-1 expression levels were evaluated by ELISA assay. The data obtained were statistically analyzed using the Mann-Whitney test. P-Values <0.05 were considered as significant. RESULTS: MCP-1 concentrations (median; range of values) in serum were as follows: women with endometriosis (221; 101-635 pg/ml), women with unexplained infertility (167, 114-234 pg/ml), women with uterine leiomyoma (137; 88-200 pg/ml), and healthy donors (123; 98-194 pg/ml). Significant differences were observed in the women with endometriosis compared with those with uterine leiomyoma (p = 0.02) and healthy donors (p = 0.002). Among the women with endometriosis, the level of significance in MCP-1 level at rAFS stages III-IV was higher than that at rAFS stages I-II compared with healthy donors and women with leiomyoma (p = 0.002 and p = 0.02, respectively). CONCLUSIONS: These data show that an increased level of MCP-1 can characterize infertile women with endometriosis. However, further studies are needed to be able to determine whether increased MCP-1 chemokine expression can be related to infertility or is a result of endometriosis progress.

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Condition tags

endometriosis

MeSH descriptors

Chemokine CCL2 Endometriosis Infertility, Female Adult Adult Biomarkers Biomarkers Biomarkers Chemokine CCL2 Chemokine CCL2 Endometriosis Endometriosis Enzyme-Linked Immunosorbent Assay Enzyme-Linked Immunosorbent Assay Female Female Humans Humans Infertility, Female Infertility, Female

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