Experimental Intestinal Endometriosis Is Characterized by Increased Levels of Soluble TNFRSF1B and Downregulation of Tnfrsf1a and Tnfrsf1b Gene Expression1

Carmencita Rojas‐Cartagena, Carmencita Rojas-Cartagena, Rojas-Cartagena C, Caroline B. Appleyard, Santiago OI, Olga I. Santiago, Idhaliz Flores
Biology of reproduction · 2005 · vol. 73(6) , pp. 1211–1218 · doi:10.1095/biolreprod.105.044131 · PMID:16093357 · W2143344885
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In a rat model of intestinal endometriosis, increased peritoneal fluid levels of TNF and soluble TNFRSF1B were observed alongside downregulated expression of Tnfrsf1a and Tnfrsf1b genes in the intestines.

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Abstract

Endometriosis is commonly associated with symptoms similar to those of gastrointestinal diseases, such as inflammatory bowel disease (IBD), leading to erroneous diagnosis and inappropriate management. The role of tumor necrosis factor alpha (TNF) in IBD is well established, but its role in endometriosis--also characterized by the activation of inflammatory mechanisms--is still under study. Furthermore, little is known about the involvement of TNF receptors. Intestinal endometriosis was surgically induced in female Sprague-Dawley rats (n = 10). Control rats (n = 10) received sutures with no implants. Samples of tissue and fluids were collected 60 days after surgery. Endometriotic implants were classified in grades, and the gastrointestinal tract was examined for damage. A significant increase was observed in protein levels of TNF and soluble TNFRSF1B in the peritoneal fluid of experimental rats compared to controls. Expression of Tnf mRNA was significantly increased both in peritoneal leukocytes and in intestinal segments associated with implants in experimental animals. Bioactivity of TNF in tissues was confirmed by overexpression of Icam1, Sele, Vegfa, Flt1 and Kdr. Gene expression of Tnfrsf1a and Tnfrsf1b was downregulated in colon and small intestine of experimental animals, possibly as a mechanism of protection against TNF cytotoxicity. Significant overexpression of genes encoding TNF receptor-associated factors that have been linked to activation of antiapoptotic pathways also was observed. Overexpression of TNF and target genes, underexpression of TNF-receptor genes, and increased shedding of TNFRSF1B in this animal model provide further evidence for involvement of the TNF system in the pathogenesis of endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Intestinal Diseases Receptors, Tumor Necrosis Factor, Type I Receptors, Tumor Necrosis Factor, Type II Receptors, Tumor Necrosis Factor, Type II Animals Disease Models, Animal Down-Regulation Endometriosis Endometriosis Endometriosis E-Selectin E-Selectin Female Gene Expression Regulation Intercellular Adhesion Molecule-1 Intestinal Diseases Intestinal Diseases Intestinal Diseases Leukocyte Count

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