Gene Expression Profiling of the Rat Endometriosis Model

Ryo Konno, Hiroyuki Fujiwara, Sachiho Netsu, Kohei Odagiri, Miyuki Shimane, Hitoshi Nomura, Mitsuaki Suzuki
American journal of reproductive immunology (New York, N.Y. : 1989) · 2007 · vol. 58(4) , pp. 330–343 · doi:10.1111/j.1600-0897.2007.00507.x · PMID:17845203 · W2060237972
article OA: closed CC0 ⤵ 44 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-09 ⓘ

Gene expression profiling of a rat endometriosis model revealed 71 upregulated and 45 downregulated genes in endometriotic lesions compared to normal uterine tissue.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

PROBLEM: To investigate the molecular mechanism of endometriosis, gene expression profiling was analyzed in a rat endometriosis model. METHOD OF STUDY: An endometriosis model was induced by uterine autotransplantation in the peritoneal cavity on a female-SD rat (8 weeks old). As control samples, the normal uterine tissues were used. The gene expression was compared between endometriotic lesions and normal uterine tissues by cDNA microarray analysis, quantitative real time RT-PCR and immunohistochemistry. RESULTS: The expression of 71 genes was upregulated and that of 45 genes was downregulated in the endometriotic lesions compared to normal uterine tissues. The upregulated genes included genes encoding cytokines, chemokines, growth factors and cell adhesion molecules. The levels of transcripts of osteopontin, Lyn, Vav1, Runx1, and l-selectin in the endometriotic lesions were 130, 10, 10, 12 and 46-fold higher than the respective levels in the eutopic endometrial samples. CONCLUSION: The results suggest that osteopontin, Lyn, Vav1, Runx1, and l-selectin play important roles in the pathogenesis of endometriosis.

My notes (saved in your browser only)

Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Gene Expression Profiling Gene Expression Profiling Gene Expression Regulation Animals Core Binding Factor Alpha 2 Subunit Core Binding Factor Alpha 2 Subunit Core Binding Factor Alpha 2 Subunit Disease Models, Animal Endometriosis Endometriosis Endometriosis Female Immunohistochemistry L-Selectin L-Selectin L-Selectin Oligonucleotide Array Sequence Analysis Osteopontin Osteopontin

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (53)

Cited by (44)

Source provenance

europepmc
last seen: 2026-06-04T01:30:01.192114+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:14:48.452140+00:00
License: CC0 · commercial use OK