The Effect of Chinese Herbs on the Cytokines of Rats with Endometriosis
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YiWeiNing treatment reduced elevated TNF-alpha, IL-6, and IL-8 levels in rats with endometriosis, suggesting inhibition of ectopic endometrial growth.
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Abstract
OBJECTIVE: The aim of this study was to study the regulatory function of Chinese medicine-YiWeiNing (YWN) on the cytokines of endometriosis (EM) model rats. MATERIALS AND METHODS: After successfully creating EM models of rats, all were separated randomly into five groups: high dose of YWN (5.4 g/100 g), low dose of YWN (1.8 g/100 g), Danazol group (3.6 mg/100 g), a model group, and a false-operation group. They were then reviewed for the variation of the amount of TNF-alpha (tumor necrosis factor-alpha), interleukin-6 (IL-6), and interleukin-8 (IL-8). RESULTS: The content of TNF-alpha, IL-6, and IL-8 in the peripheral blood of the model group was apparently higher than the false-operation group (p < 0.01), and YWN reduced the amount of TNF-alpha, IL-6, and IL-8 in the serums of the model group's rats. This made these cytokines tend toward normal levels without an apparent variation, when compared with the false-operation group (p > 0.05). CONCLUSIONS: YWN can prevent the growth of ectopic endometrium by inhibiting the synthesis and secretion of TNF-alpha, IL-6, and IL-8.
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References (10)
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- Local Cytokines in Endometrial Tissue: The Role of Interleukin‐8 in the Pathogenesis of Endometriosis via openalex
- Regulation of Interleukin-8 Expression in Human Endometrial Endothelial Cells: A Potential Mechanism for the Pathogenesis of Endometriosis via openalex
- Role of Cytokines in Endometriosis-Associated Infertility via openalex
- The Role of Cytokines in Endometriosis* via openalex
- Tumor Necrosis Factor- Promotes Proliferation of Endometriotic Stromal Cells by Inducing Interleukin-8 Gene and Protein Expression via openalex
- W2042642675 via openalex
Cited by (9)
- Endometriosis: current challenges in modeling a multifactorial disease of unknown etiology 2020
- Understanding the Role of Gui‐Zhi‐Fu‐Ling‐Capsules (Chinese Medicine) for Treatment of Endometriosis in the Rat Model: Using NMR Based Metabolomics 2018
- The oil-resin of the tropical rainforest tree <i>Copaifera langsdorffii</i> reduces cell viability, changes cell morphology and induces cell death in human endometriotic stromal cultures 2015
- Effects of Chinese materia medica-fuboa danggui jiao on experimental endometriosis 2011
- Treating gynaecological disorders with traditional Chinese medicine: a review 2010
- A Botanical Extract from Channel Flow Inhibits Cell Proliferation, Induces Apoptosis, and Suppresses CCL5 in Human Endometriotic Stromal Cells1 2009
- Endometrial paradigms 2008
- Gene Expression Profiling of the Rat Endometriosis Model 2007
- Evolution of medical treatment for endometriosis: back to the roots? 2007
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- europepmc
- last seen: 2026-06-04T01:30:01.192114+00:00
- openalex
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- pubmed
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