Effects of Chinese Materia Medica-Fubao Danggui Jiao on experimental endometriosis

Xing Sun, Shijie Xing, Sun X, Chen L, C Lijue, Lijue Chen, Fanbo Zeng, Zeng F, Z Fanbo
African journal of traditional, complementary, and alternative medicines : AJTCAM · 2011 · vol. 8(3) , pp. 224–9 · doi:10.4314/ajtcam.v8i3.65283 · PMID:22468001 · PMC3252223 · W1491289592
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-07 ⓘ

Fubao Danggui Jiao (FDJ) treatment in rats with experimentally induced endometriosis significantly decreased endometriotic implant volumes and caused regression of implant epithelium and stroma.

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⚙ AI-generated deep summary by qwen3.7-flash, 2026-08-27 · read from full text ⓘ

This study investigated the therapeutic potential of Fubao Danggui Jiao (FDJ), a Chinese herbal medicine, using an experimental rat model induced by autotransplanting endometrial tissue onto the abdominal wall. Forty rats were divided into control and treatment groups receiving either FDJ at two different doses or Danazol for thirty days, after which implant volumes and histological changes were assessed. The results demonstrated that FDJ significantly reduced the volume of endometriotic implants and promoted the regression of both epithelial and stromal components, with effects comparable between the two administered doses. This paper is centrally about endometriosis — specifically evaluating a traditional Chinese medicine intervention in an animal model of the disease.

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Abstract

The objective of this paper was to investigate the effects of a Chinese Materia Medica variant -Fubao Danggui Jiao (FDJ)-on experimental endometriosis. An endometriosis model was created by virtue of auto-transplantation of endometrial tissue onto rats' abdominal walls. The implants were allowed to grow for 30 days until the successful completion of the model. After that, forty endometriotic rats were randomly divided into four study groups and given different treatments: (1) negative control group (water, 2ml/kg, per os); (2) FDJ-A group (FDJ, 2ml/kg, per os); (3) FDJ-B group (FDJ, 4ml/kg, per os); (4) Danazol group (70mg/kg, per os). After 30 days with treatments, the volumes of endometriotic implants in each rat were measured. The implants and normal uterine horns were removed for routine histological examination. FDJ caused significant decreases in volumes of the surviving endometriotic implants, with two different doses having statistically equivalent effects. Upon histological examination, FDJ was observed to cause regression of epithelium and stroma of endometriotic implants. FDJ had revealed promising therapeutic effects on endometriosis.
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Abstract

The objective of this paper was to investigate the effects of a Chinese Materia Medica variant -Fubao Danggui Jiao (FDJ)-on experimental endometriosis. An endometriosis model was created by virtue of auto-transplantation of endometrial tissue onto rats’ abdominal walls. The implants were allowed to grow for 30 days until the successful completion of the model. After that, forty endometriotic rats were randomly divided into four study groups and given different treatments: (1) negative control group (water, 2ml/kg, per os); (2) FDJ-A group (FDJ, 2ml/kg, per os); (3) FDJ-B group (FDJ, 4ml/kg, per os); (4) Danazol group (70mg/kg, per os). After 30 days with treatments, the volumes of endometriotic implants in each rat were measured. The implants and normal uterine horns were removed for routine histological examination. FDJ caused significant decreases in volumes of the surviving endometriotic implants, with two different doses having statistically equivalent effects. Upon histological examination, FDJ was observed to cause regression of epithelium and stroma of endometriotic implants. FDJ had revealed promising therapeutic effects on endometriosis.

Keywords

Fubao Danggui Jiao; Chinese Materia Medica; Endometriosis; Danazol. Non-standard Abbreviations: Fubao Danggui Jiao - FDJ

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometrium Materia Medica Medicine, Chinese Traditional Medicine, Chinese Traditional Abdominal Wall Abdominal Wall Abdominal Wall Animals Animals Disease Models, Animal Disease Models, Animal Dose-Response Relationship, Drug Dose-Response Relationship, Drug Endometriosis Endometriosis Endometriosis Endometrium Endometrium Endometrium

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