EFFECTS OF DANCHI DECOCTION ON P450AROM, SURVIVIN OF EUTOPIC ENDOMETRIUM OF PATIENTSWITH ENDOMETRIOSIS AFTER CONSERVATIVE SURGERY

Yanhuan Yang, Ruihua Zhao, Zengping Hao, Li Li, Cai Xu, Yangyang Cui
In: African Journal of Traditional, Complementary and Alternative Medicines · 2015 · vol. 12(4) , pp. 65–71 · doi:10.21010/ajtcam.v12i4.10 · W1606257993
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Danchi decoction treatment of endometriosis patients post-surgery significantly decreased eutopic endometrial P450arom and survivin expression compared to before treatment.

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Abstract

Background: Endometriosis is a common gynecological disease, which can seriously affect the physical and mental health of patients. However, there is not a satisfactory way to treat endometriosis with a low recurrence rate. Materials and Methods: Including twenty patients with endometriosis given conservative surgery, a prospective clinical study was performed with randomly grouping and positive control. The traditional Chinese medicine (TCM) and western medicine (WM) groups were given Danchi decoction and GnRH-a or gestrinone respectively. Treatment was given in 1–5 days during the first menstruation. The eutopic endometriums were collected before and 3 months after the treatment, respectively. Then immunohistochemistry was performed to obtain the expressions of P450arom and survivin. In the normal control (NC) group no drugs were administered. Results: Before the treatment, the expressions of P450arom and survivin in both TCM and WM groups were much higher than the NC group (P0.05). The expressions of the two groups were remarkably decreased after the treatment (P0.05). Conclusion: Danchi decoction can control the recurrence of endometriosis by restraining abnormal secretion of aromatizing enzyme and regulating cell apoptosis in eutopic endometrium. Excessive expressions of aromatizing enzyme and decreased apoptosis are a possible mechanism of endometriosis recurrence.
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EFFECTS OF DANCHI DECOCTION ON P450AROM, SURVIVIN OF EUTOPIC ENDOMETRIUM OF PATIENTSWITH ENDOMETRIOSIS AFTER CONSERVATIVE SURGERY DOI: https://doi.org/10.21010/ajtcam.v12i4.10Keywords: Endometriosis, Recurrence, Danchi Decoction, Eutopic endometriumAbstract Background: Endometriosis is a common gynecological disease, which can seriously affect the physical and mental health of patients. However, there is not a satisfactory way to treat endometriosis with a low recurrence rate. Materials and Methods: Including twenty patients with endometriosis given conservative surgery, a prospective clinical study was performed with randomly grouping and positive control. The traditional Chinese medicine (TCM) and western medicine (WM) groups were given Danchi decoction and GnRH-a or gestrinone respectively. Treatment was given in 1–5 days during the first menstruation. The eutopic endometriums were collected before and 3 months after the treatment, respectively. Then immunohistochemistry was performed to obtain the expressions of P450arom and survivin. In the normal control (NC) group no drugs were administered. Results: Before the treatment, the expressions of P450arom and survivin in both TCM and WM groups were much higher than the NC group (P0.05). The expressions of the two groups were remarkably decreased after the treatment (P0.05). Conclusion: Danchi decoction can control the recurrence of endometriosis by restraining abnormal secretion of aromatizing enzyme and regulating cell apoptosis in eutopic endometrium. Excessive expressions of aromatizing enzyme and decreased apoptosis are a possible mechanism of endometriosis recurrence.Downloads Published How to Cite Issue Section License Copyright: Creative Commons Attribution CC. This license lets others distribute, remix, tweak, and build upon your work, even commercially, as long as they credit you for the original creation. This is the most accommodating of licenses offered. Recommended for maximum dissemination and use of licensed materials. View License Deed | View Legal Code Authors can also self-archive their manuscripts immediately and enable public access from their institution's repository. This is the version that has been accepted for publication and which typically includes author-incorporated changes suggested during submission, peer review and in editor-author communications.

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