Comparative study on the efficacy of Yiweining and gestrinone for post-operational treatment of stage III endometriosis

Dong-xia Yang, Dongxia Yang, Ma Wen-guang, Wen-guang Ma, Fan Qu, MA Bao-zhang, Bao-zhang Ma
Chinese journal of integrative medicine · 2006 · vol. 12(3) , pp. 218–220 · doi:10.1007/bf02836527 · PMID:17005086 · W2083667580
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-07 ⓘ

Yiweining (YWN) and gestrinone (GT) showed similar low recurrence rates for stage III endometriosis post-operation, but YWN had a lower adverse reaction rate than GT.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 · read from full text ⓘ

This paper compared the efficacy and safety of Yiweining (YWN) versus gestrinone (GT) for post-operative treatment of stage III endometriosis in 52 patients randomized into two treated groups (YWN, n=20; GT, n=19) and an untreated control group (n=13). Treatments were initiated 7 days after surgery for GT and for 6 months overall, with recurrence monitored during follow-up lasting 6–30 months after medication ended. Recurrence rates were similarly low in the YWN (5.0%) and GT (5.3%) groups and significantly lower than in controls (30.7%), while the adverse reaction rate was lower with YWN than GT (10.0% vs 31.6%). The paper does not clearly state all methodological caveats in the provided text (e.g., blinding), and it reports results for this specific stage and post-operative context; This paper is centrally about endometriosis — it directly evaluates post-operational prevention of recurrence in stage III endometriosis using Yiweining compared with gestrinone and an untreated group.

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Abstract

Objective: To observe the clinical efficacy and safety of Yiweining, (YWN) and gestrinone (GT) in treating post-operational patients of stage III endometriosis (EM-III).Methods: Fifty-two patients of EM-III after operation were randomly assigned into three groups, the YWN group (20 patients) was treated through oral intake of YWN 200 ml, twice a day;the GT group (19 patients) treated with gestrinone 2.5 mg, twice every week, with the medication starting from the 7th post-operational day and lasting for 6 months. The control group (13 patients) was untreated. Six months was one therapeutic course, and follow-up study was carried out in the 6 –30 months after the end of the medication.Results: The recurrence rate in the YWN group and the GT group were 5.0% and 5.3% respectively, showing insignificant difference between the two groups, but they were lower than that in the control group (30.7%,P < 0.05). Besides, the adverse reaction rate in the YWN group was lower than that in the GT group (10.0% vs 31.6%,P < 0.05).Conclusion: Application of YWN to prevent the post-operational recurrence of endometriosis is effective and safe, and its efficacy is similar to that of GT. Similar content being viewed by others

References

American Fertility Society. Revised American fertility society classification of endometriosis: 1985. Fertil Steril 1985; 43(3): 351–352. Shu J, Fang SH, Sheng LF, et al. Clinical observation on the effects of mifepristone and gestrinone treatment for postoperative patients with severe pelvic endometriosis. Chin J Pract Gynecol Obstet 2002;18(3): 181–183. Blumenfeld Z. Hormonal suppressive therapy for endometriosis may not improve patient health. Fertil Steril 2004;81 (3): 487–492. Cao YZ, editor. Chinese obstetrics and gynecology. Beijing: People’s Medical Publishing House, 1999: 1291 Situ Y, Yang JL. Special edition of gynecopathy. Clinical diagnosis and therapy series of traditional Chinese medicine. 2nd ed. Beijing: People’s Medical Publishing House, 2005: 635. Xu BS, Cai YP, Li Y, et al. Expression of Bcl-2 in eutopic and ectopic endometrium of EMT model rats treated with traditional Chinese medicine. Chin J Histochem Cytochem 2004;13(4): 489–493. Yu XH, Huang GY, Lu FE, et al. Effect of promote-bloodflow decoction on proliferation of ectopic endometrim cells in an endometriosis rat model. J Huazhong Univ Sci Technol (Health Sci) 2006;35(1): 93–95. Author information Authors and Affiliations Corresponding author Additional information Supported by the Fund of Natural Sciene of Heilongjiang Province (2004-D55) Rights and permissions About this article Cite this article Dong-xia, Y., Wen-guang, M., Fan, Q. et al. Comparative study on the efficacy of Yiweining and gestrinone for post-operational treatment of stage III endometriosis. Chin. J. Integr. Med. 12, 218–220 (2006). https://doi.org/10.1007/BF02836527 Received: Issue date: DOI: https://doi.org/10.1007/BF02836527

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Drugs, Chinese Herbal Endometriosis Gestrinone Progestins Administration, Oral Adult Drugs, Chinese Herbal Drugs, Chinese Herbal Endometriosis Endometriosis Endometriosis Female Follow-Up Studies Gestrinone Gestrinone Humans Postoperative Complications Postoperative Complications Postoperative Complications Pregnancy

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