{"paper_id":"af7d632e-c1d0-4aae-bb43-78aa970fa15c","body_text":"Abstract\nObjective: To observe the clinical efficacy and safety of Yiweining, (YWN) and gestrinone (GT) in treating post-operational patients of stage III endometriosis (EM-III).Methods: Fifty-two patients of EM-III after operation were randomly assigned into three groups, the YWN group (20 patients) was treated through oral intake of YWN 200 ml, twice a day;the GT group (19 patients) treated with gestrinone 2.5 mg, twice every week, with the medication starting from the 7th post-operational day and lasting for 6 months. The control group (13 patients) was untreated. Six months was one therapeutic course, and follow-up study was carried out in the 6 –30 months after the end of the medication.Results: The recurrence rate in the YWN group and the GT group were 5.0% and 5.3% respectively, showing insignificant difference between the two groups, but they were lower than that in the control group (30.7%,P < 0.05). Besides, the adverse reaction rate in the YWN group was lower than that in the GT group (10.0% vs 31.6%,P < 0.05).Conclusion: Application of YWN to prevent the post-operational recurrence of endometriosis is effective and safe, and its efficacy is similar to that of GT.\nSimilar content being viewed by others\nReferences\nAmerican Fertility Society. Revised American fertility society classification of endometriosis: 1985. Fertil Steril 1985; 43(3): 351–352.\nShu J, Fang SH, Sheng LF, et al. Clinical observation on the effects of mifepristone and gestrinone treatment for postoperative patients with severe pelvic endometriosis. Chin J Pract Gynecol Obstet 2002;18(3): 181–183.\nBlumenfeld Z. Hormonal suppressive therapy for endometriosis may not improve patient health. Fertil Steril 2004;81 (3): 487–492.\nCao YZ, editor. Chinese obstetrics and gynecology. Beijing: People’s Medical Publishing House, 1999: 1291\nSitu Y, Yang JL. Special edition of gynecopathy. Clinical diagnosis and therapy series of traditional Chinese medicine. 2nd ed. Beijing: People’s Medical Publishing House, 2005: 635.\nXu BS, Cai YP, Li Y, et al. Expression of Bcl-2 in eutopic and ectopic endometrium of EMT model rats treated with traditional Chinese medicine. Chin J Histochem Cytochem 2004;13(4): 489–493.\nYu XH, Huang GY, Lu FE, et al. Effect of promote-bloodflow decoction on proliferation of ectopic endometrim cells in an endometriosis rat model. J Huazhong Univ Sci Technol (Health Sci) 2006;35(1): 93–95.\nAuthor information\nAuthors and Affiliations\nCorresponding author\nAdditional information\nSupported by the Fund of Natural Sciene of Heilongjiang Province (2004-D55)\nRights and permissions\nAbout this article\nCite this article\nDong-xia, Y., Wen-guang, M., Fan, Q. et al. Comparative study on the efficacy of Yiweining and gestrinone for post-operational treatment of stage III endometriosis. Chin. J. Integr. Med. 12, 218–220 (2006). https://doi.org/10.1007/BF02836527\nReceived:\nIssue date:\nDOI: https://doi.org/10.1007/BF02836527","source_license":"CC0","license_restricted":false}