Extracts of Salvia miltiorrhiza bunge on the cytokines of rat endometriosis models

Z-H Zhou, Zhou ZH, Zan-hua Zhou, Weng Q, Qihao Weng, Qing Weng, JH Zhou, Zhou JH, Jian-Hong Zhou, Zhou J, Jue Zhou
African journal of traditional, complementary, and alternative medicines : AJTCAM · 2012 · vol. 9(3) , pp. 303–14 · doi:10.4314/ajtcam.v9i3.2 · PMID:23983360 · PMC3746666 · W2088609671
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Extracts of *Salvia miltiorrhiza* bunge, particularly those extracted via coffee machine, reduced serum CA-125 and peritoneal IL-18/TNF-alpha while increasing IL-13 in rat endometriosis models.

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This study investigated the therapeutic potential of Salvia miltiorrhiza Bunge extracts in a rat model of endometriosis by comparing various extraction methods and measuring specific biomarkers. Researchers administered the extracts to female Sprague-Dawley rats with induced endometriosis, alongside control groups treated with Danazol or sham operations, and analyzed serum CA-125 and peritoneal fluid cytokines including IL-13, IL-18, and TNF-alpha. The results indicated that the extracts significantly reduced levels of CA-125, IL-18, and TNF-alpha while increasing IL-13 levels, demonstrating efficacy comparable to the positive control drug Danazol. This paper is centrally about endometriosis — specifically evaluating the anti-inflammatory effects of herbal extracts on disease markers in an animal model.

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Abstract

Endometriosis is a common mysterious and fascinating gynaecological condition with diverse clinical manifestations, highly variable and unpredictable clinical course with decreased quality of life. Clinically, Salvia miltiorrhiza Bunge (SMB, Chinese Danshen) has been applied to treat endometriosis and get satisfactory results. The present study was aimed to explore the effects of the extracts of SMB (ESMB) on the serum levels of cancer antigen 125 (CA-125) and the levels of interleukin (IL)-13, IL-18 and tumor necrosis factor-alpha (TNF-alpha) in the peritoneal fluids of rat endometriosis models. Three extraction methods for SMB were compared, which are the sample extracted with conventional method, the sample extracted with espresso coffee machine and the commercial condensed powder of natural products. We determined tanshinone IIA, salvianolic acid B and danshensu in the ESMB of different extraction methods. Forty female Sprague-Dawley (SD) rats were randomly divided into ESMB group, Danazol (positive control) group, model group and the sham-operation group (Sham group). After all the treatment ended, the serum levels of CA125 and the levels of IL-13, IL-18 and TNF-alpha in the peritoneal fluids of rat endometriosis models were measured using enzyme-linked immune-sorbent assay (ELISA) as directed by the manufacturer. The extraction efficiency of the ESMB samples extracted with coffee machine ranged from 600µm to 710µm was the highest. The serum levels of CA-125 and the levels of IL-18 and TNF-alpha in the peritoneal fluids of ESMB group, Danazol group and Sham group were significantly lower than those of the Model group (P<0.05). The serum levels of CA-125 and the levels of IL-18 and TNF-alpha in the peritoneal fluids of Danazol group and ESMB group were significantly higher than those of Sham group, respectively (P0.05). The levels of IL-13 in the peritoneal fluids of ESMB group, Danazol group and Sham group were significantly higher than those of the Model group (P<0.05). The levels of IL-13 in the peritoneal fluids of ESMB group and Danazol group were significantly lower than those of Sham group (P0.05). ESMB shows promises in treating endometriosis by markedly decreasing the serum levels of CA-125 and the levels of IL-18 and TNF-alpha in the peritoneal fluids and significantly increasing the levels of IL-13 in the peritoneal fluids.
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Main Article Content Extracts of Salvia miltiorrhiza bunge on the cytokines of rat endometriosis models Abstract IL-13 in the peritoneal fluids. Journal / African Journal of Traditional, Complementary and Alternative Medicines / Vol. 9 No. 3 (2012) / Articles Endometriosis is a common mysterious and fascinating gynaecological condition with diverse clinical manifestations, highly variable and unpredictable clinical course with decreased quality of life. Clinically, Salvia miltiorrhiza Bunge (SMB, Chinese Danshen) has been applied to treat endometriosis and get satisfactory results. The present study was aimed to explore the effects of the extracts of SMB (ESMB) on the serum levels of cancer antigen 125 (CA-125) and the levels of interleukin (IL)-13, IL-18 and tumor necrosis factor-alpha (TNF-alpha) in the peritoneal fluids of rat endometriosis models. Three extraction methods for SMB were compared, which are the sample extracted with conventional method, the sample extracted with espresso coffee machine and the commercial condensed powder of natural products. We determined tanshinone IIA, salvianolic acid B and danshensu in the ESMB of different extraction methods. Forty female Sprague-Dawley (SD) rats were randomly divided into ESMB group, Danazol (positive control) group, model group and the sham-operation group (Sham group). After all the treatment ended, the serum levels of CA125 and the levels of IL-13, IL-18 and TNF-alpha in the peritoneal fluids of rat endometriosis models were measured using enzyme-linked immune-sorbent assay (ELISA) as directed by the manufacturer. The extraction efficiency of the ESMB samples extracted with coffee machine ranged from 600ìm to 710ìm was the highest. The serum levels of CA-125 and the levels of IL-18 and TNF-alpha in the peritoneal fluids of ESMB group, Danazol group and Sham group were significantly lower than those of the Model group (P<0.05). The serum levels of CA-125 and the levels of IL-18 and TNF-alpha in the peritoneal fluids of Danazol group and ESMB group were significantly higher than those of Sham group, respectively (P0.05). The levels of IL-13 in the peritoneal fluids of ESMB group, Danazol group and Sham group were significantly higher than those of the Model group (P<0.05). The levels of IL-13 in the peritoneal fluids of ESMB group and Danazol group were significantly lower than those of Sham group (P0.05). ESMB shows promises in treating endometriosis by markedly decreasing the serum levels of CA-125 and the levels of IL-18 and TNF-alpha in the peritoneal fluids and significantly increasing the levels of IL-13 in the peritoneal fluids. IL-13 in the peritoneal fluids. eISSN: 0189-6016

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Condition tags

endometriosis

MeSH descriptors

Ascitic Fluid CA-125 Antigen Cytokines Drugs, Chinese Herbal Endometriosis Phytotherapy Salvia miltiorrhiza Animals Ascitic Fluid CA-125 Antigen CA-125 Antigen Cytokines Cytokines Danazol Danazol Danazol Disease Models, Animal Drugs, Chinese Herbal Drugs, Chinese Herbal Endometriosis

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