CA 125 serum values in surgically treated endometriosis patients and its relationships with anatomic sites of endometriosis and pregnancy rate

Patrelli TS, Tito Silvio Patrelli, Roberto Berretta, Salvatore Gizzo, Gizzo S, Antonio Pezzuto, Pezzuto A, Franchi L, Laura Franchi, Lukanovic A, Adolf Lukanović, Adolf Lukanovic, Nardelli GB, Giovanni Battista Nardelli, Modena AB, Alberto Bacchi Modena
Fertility and sterility · 2010 · vol. 95(1) , pp. 393–396 · doi:10.1016/j.fertnstert.2010.08.043 · PMID:20934691 · W2032186935
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This study investigated CA 125 serum levels in surgically treated endometriosis patients and their correlation with the anatomic sites of the disease and pregnancy rates.

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Abstract

Endometriosis is a benign gynecologic disease defined as the presence of functional endometrial glands and stroma outside the uterine cavity, causing dysmenorrhea, dyspareunia, menstrual irregularities, and infertility. Serum CA-125 measurement is now a consolidated method for diagnosing this condition, and its interpretation has posed a number of problems, particularly regarding utility in diagnosing minimal-mild endometriosis, whereas its value as a diagnostic aid in moderate-severe stages is well recognized. In our cohort, serum CA-125 values were significantly elevated in patients with ovarian and mixed endometriosis lesions (median levels 48 U/mL), compared with those who had exclusively extraovarian foci (median levels 27 U/mL), and so the correlation between this marker and the surgical and pathologic finding of ovarian and deep endometriosis was found to be statistically significant; however, the location did not affect the fertility rate.

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Condition tags

endometriosischronic_pelvic_pain

MeSH descriptors

Biomarkers CA-125 Antigen Endometriosis Endometriosis Endometriosis Endometriosis Pregnancy Rate Adult Biomarkers CA-125 Antigen Endometrium Endometrium Female Humans Ovary Ovary Pelvic Pain Pelvic Pain Pelvic Pain Pelvic Pain

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (39)

Cited by (26)

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