Is it time to consider patients suffering from endometriosis-related infertility as “novel candidates” for targeted peri-conceptional D-chiro inositol supplementation? Hypothesis, rationale and some considerations

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This paper proposes considering D-chiro inositol supplementation for infertile women with endometriosis due to potential benefits for oocyte and embryo quality and metabolic factors.

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This paper is a hypothesis/rationale article proposing that women with endometriosis-related infertility could be “novel candidates” for targeted peri-conceptional D-chiro inositol supplementation, with the argument framed around inositol’s roles in insulin signaling and oxidative/metabolic pathways relevant to reproduction. It synthesizes prior findings from the broader literature (including data connecting endometriosis with redox alterations and infertility biomarkers, and evidence of D-chiro inositol metabolic effects in other infertile populations) but does not report original experiments or clinical trial outcomes. A key caveat is that the work is conceptual and depends on literature inference, with no direct evaluation of D-chiro inositol peri-conceptional effects specifically in endometriosis-related infertility. This paper is centrally about endometriosis-related infertility — it specifically discusses whether peri-conceptional D-chiro inositol supplementation should be considered for that patient group.

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References Piomboni P, Focarelli R, Capaldo A, Stendardi A, Cappelli V, Cianci A, et al. Protein modification as oxidative stress marker in follicular fluid from women with polycystic ovary syndrome: the effect of inositol and metformin. J Assist Reprod Genet. 2014;31(10):1269–76. Gizzo S, Capuzzo D, Zicchina C, Di Gangi S, Coronella ML, Andrisani A, et al. Could empirical low-dose-aspirin administration during IVF cycle affect both the oocytes and embryos quality via COX 1–2 activity inhibition? J Assist Reprod Genet. 2014;31(3):261–8. Jancar N, Kopitar AN, Ihan A, Virant Klun I, Bokal EV. Effect of apoptosis and reactive oxygen species production in human granulosa cells on oocyte fertilization and blastocyst development. J Assist Reprod Genet. 2007;24(2–3):91–7. Hennet ML, Yu HY, Combelles CM. Follicular fluid hydrogen peroxide and lipid hydroperoxide in bovine antral follicles of various size, atresia, and dominance status. J Assist Reprod Genet. 2013;30(3):333–40. Patrelli TS, Berretta R, Gizzo S, Pezzuto A, Franchi L, Lukanovic A, et al. CA 125 serum values in surgically treated endometriosis patients and its relationships with anatomic sites of endometriosis and pregnancy rate. Fertil Steril. 2011;95(1):393–6. Choi YS, Cho S, Seo SK, Park JH, Kim SH, Lee BS. Alteration of the intrafollicular thiol-redox system in infertile women with endometriosis. Reproduction. 2014 Nov 5. pii: REP-14-0438. Cohen J, Ziyyat A, Naoura I, Chabbert-Buffet N, Aractingi S, Darai E, Lefevre B. Effect of induced peritoneal endometriosis on oocyte and embryo quality in a mouse model. J Assist Reprod Genet. 2014 Nov 16. McKinnon B, Bertschi D, Wotzkow C, Bersinger NA, Evers J, Mueller MD. Glucose transporter expression in eutopic endometrial tissue and ectopic endometriotic lesions. J Mol Endocrinol. 2014;52(2):169–79. Melo AS, Rosa-e-Silva JC, Rosa-e-Silva AC, Poli-Neto OB, Ferriani RA, Vieira CS. Unfavorable lipid profile in women with endometriosis. Fertil Steril. 2010;93(7):2433–6. Polak G, Barczyński B, Kwaśniewski W, Bednarek W, Wertel I, Derewianka-Polak M, et al. Low-density lipoproteins oxidation and endometriosis. Mediators Inflamm. 2013;2013:624540. Nestler JE, Jakubowicz DJ, Reamer P, Gunn RD, Allan G. Ovulatory and metabolic effects of D-chiro-inositol in the polycystic ovary syndrome. N Engl J Med. 1999;340(17):1314–20. Larner J, Brautigan DL, Thorner MO. D-chiro-inositol glycans in insulin signaling and insulin resistance. Mol Med. 2010;16(11–12):543–52. Tamura H, Takasaki A, Nakamura Y, Numa F, Sugino N. A pilot study to search possible mechanisms of ultralong gonadotropin-releasing hormone agonist therapy in IVF-ET patients with endometriosis. J Ovarian Res. 2014;7(1):100. Vitagliano A, Noventa M, Gizzo S. Emerging evidence regarding statins use as novel endometriosis targeted treatment: real “magic pills” or “trendy” drugs? Some considerations. Eur J Obstet Gynecol Reprod Biol. 2014, In Press. (http://dx.doi.org/10.1016/j.ejogrb.2014.11.018) Author information Authors and Affiliations Corresponding author Rights and permissions About this article Cite this article Vitagliano, A., Noventa, M. & Gizzo, S. Is it time to consider patients suffering from endometriosis-related infertility as “novel candidates” for targeted peri-conceptional D-chiro inositol supplementation? Hypothesis, rationale and some considerations. J Assist Reprod Genet 32, 407–408 (2015). https://doi.org/10.1007/s10815-014-0412-z Received: Accepted: Published: Issue date: DOI: https://doi.org/10.1007/s10815-014-0412-z

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Condition tags

endometriosisinfertility

MeSH descriptors

Biomarkers Inositol Metformin Oxidative Stress Polycystic Ovary Syndrome Protein Processing, Post-Translational Biomarkers Female Humans Inositol Metformin Oxidative Stress Polycystic Ovary Syndrome Protein Processing, Post-Translational

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