Low-Density Lipoproteins Oxidation and Endometriosis

Grzegorz Polak, Bartłomiej Barczyński, Wojciech Kwaśniewski, Wiesława Bednarek, Iwona Wertel, Magdalena Derewianka-Polak, Jan Kotarski
Mediators of inflammation · 2013 · vol. 2013 , pp. 1–4 · doi:10.1155/2013/624540 · PMID:23861560 · PMC3703791 · W2109154614
article OA: gold CC0 ⤵ 18 in-corpus citations
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This study found higher concentrations of oxidized low-density lipoproteins in the peritoneal fluid of women with stage IV endometriosis compared to those with serous ovarian cysts.

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Abstract

The etiopathogenesis of endometriosis still remains unknown. Recent data provide new valuable information concerning the role of oxidative stress in the pathophysiology of the disease. It has been proved that levels of different lipid peroxidation end products are increased in both peritoneal fluid (PF) and serum of endometriotic patients. We assessed the concentration of oxidized low-density lipoproteins (oxLDL) in PF of 110 women with different stages of endometriosis and 119 women with serous (n = 78) or dermoid (n = 41) ovarian cysts, as the reference groups. PF oxLDL levels were evaluated by ELISA. We found that concentrations of oxLDL in PF of endometriotic women were significantly higher compared to women with serous but not dermoid ovarian cysts. Interestingly, by analyzing concentrations of oxLDL in women with different stages of the disease, it was noted that they are significantly higher only in the subgroup of patients with stage IV endometriosis as compared to women with ovarian serous cysts. In case of minimal, mild, and moderate disease, PF oxLDL levels were similar to those noted in reference groups. Our results indicate that disrupted oxidative status in the peritoneal cavity of women with endometriosis may play a role in the pathogenesis of advanced stages of the disease.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Lipid Peroxidation Lipoproteins, LDL Ovarian Cysts Oxidative Stress Adolescent Adult Ascitic Fluid Ascitic Fluid Disease Progression Endometriosis Endometriosis Enzyme-Linked Immunosorbent Assay Female Humans Laparoscopy Lipoproteins, LDL Middle Aged Ovarian Cysts Ovarian Cysts

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References (26)

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