Increased levels of oxidative and carbonyl stress markers in normal ovarian cortex surrounding endometriotic cysts

Giovanna Di Emidio, Angela D'Alfonso, Angela D’Alfonso, Pietro Leocata, Valentina Parisse, Adina Di Fonso, Paolo Giovanni Artini, F Patacchiola, Felice Patacchiola, Carla Tatone, Gaspare Carta, G Carta
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2014 · vol. 30(11) , pp. 808–812 · doi:10.3109/09513590.2014.938625 · PMID:25030845 · W2142973634
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Normal ovarian cortex surrounding endometriotic cysts shows higher levels of oxidative and carbonyl stress markers, including FOXO3A, 8-OHdG, and AGEs, compared to tissue surrounding follicular or dermoid cysts.

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Abstract

Many evidence support the view that endometriotic cyst may exert detrimental effect on the surrounding ovarian microenvironment so representing a risk to functionality of adjacent follicles. Patients with benign ovarian cyst (endometriotic, follicular and dermoid cysts) subjected to laparoscopic cystectomy were enrolled in the present retrospective study in order to analyze whether endometriotic tissue could negatively affect the surrounding normal ovarian cortex more severely than other ovarian cysts. To this end we carried out immunohistochemistry analysis and comparative determination of the transcription factor FOXO3A, oxidized DNA adduct 8-OHdG (8-hydroxy-2'-deoxyguanosine) and damaged proteins known as AGEs (Advanced Glycation End products) as markers of ovarian stress response and molecular damage. Our results show that all the markers analyzed were present in normal ovarian tissue surrounding benign cysts. We observed higher levels of FOXO3A (15.90 ± 0.28), 8-OHdG (13.33 ± 2.07) and AGEs (12.58 ± 4.34) staining in normal ovarian cortex surrounding endometriotic cysts in comparison with follicular cysts (9.04 ± 0.29, 2.67 ± 2.67, 11.31 ± 2.95, respectively) and dermoid cysts (2.02 ± 0.18, 4.33 ± 2.58 and 10.56 ± 4.03, respectively). These results provide evidence that ovarian endometrioma is responsible for more severe alterations to cellular biomolecules than follicular and dermoid cysts.

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Condition tags

mesh:D004715endometrioma

MeSH descriptors

Endometriosis Ovarian Cysts Ovary Oxidative Stress 8-Hydroxy-2'-Deoxyguanosine Adult Biomarkers Biomarkers Deoxyguanosine Deoxyguanosine Deoxyguanosine Endometriosis Endometriosis Female Forkhead Box Protein O3 Forkhead Transcription Factors Forkhead Transcription Factors Glycation End Products, Advanced Glycation End Products, Advanced Humans

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