Effect of endometriosis and adenomyosis on oocyte quality: an evaluation of 205,978 oocytes

Kahraman S, Semra Kahraman, İpek Nur Balın Düzgüner, Duzguner I, Ipek Duzguner, Sahin Y, Yucel Sahin
Reproductive BioMedicine Online · 2025 · vol. 52(3) , pp. 105234 · doi:10.1016/j.rbmo.2025.105234 · PMID:41579461 · W4413821170
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This study evaluated 205,978 oocytes to determine the effect of endometriosis and adenomyosis on oocyte quality.

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Abstract

RESEARCH QUESTION: Does the presence of endometriosis and/or adenomyosis, adversely affect oocyte morphology? DESIGN: Retrospective, single-centre study evaluating 29,130 ART cycles between August 2011 and March 2023. Patients diagnosed with endometriosis and/or adenomyosis, were included (n = 4602 cycles; 27,204 oocytes). Two pre-defined subgroups were evaluated: adenomyosis with or without endometriosis (n = 497 patients; n = 3377 oocytes); and endometriosis-only patients (endometriosis without adenomyosis) (n = 3355 patients; n = 24,320 oocytes). The control group included all patients without endometriosis or adenomyosis. Oocyte morphology, cycle characteristics, fresh and frozen embryo transfer outcomes were compared between the study and control groups. Oocyte morphology results were reported using effect sizes owing to the large number of oocytes analysed. RESULTS: Phi effect size indicated only negligible differences in oocyte morphology between endometriosis and control groups. In endometriosis cases, a significantly lower number of aspirated, mature and fertilized oocytes were found compared with the control group (P < 0.001, all). Cliff's delta effect size indicated only negligible differences in oocyte morphology between adenomyosis and endometriosis only groups. No significant difference was found between embryo transfer outcomes. Adenomyosis with or without endometriosis patients had lower pregnancy and live birth rates (P < 0.001, both) and higher biochemical and clinical pregnancy loss rates (P = 0.009 and P = 0.01 respectively) compared with patients with endometriosis only. CONCLUSIONS: Endometriosis and adenomyosis did not affect oocyte morphology. Clinical pregnancy and live birth rates were unaffected by endometriosis. Adenomyosis increased the risk of pregnancy loss and decreased live birth rates.

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Condition tags

endometriosisadenomyosis

MeSH descriptors

Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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